- Discussion of whether capsaicin analogs or other natural TRPV1 agonists exist that do not trigger receptor down-regulation, with the suggestion that functionally-selective molecules or receptor-protein complexes could provide alternative pathways without tolerance.  
- Mention of the possibility of personally testing non-capsaicin TRPV1 agonists on willing, naïve subjects to gather anecdotal data on down-regulation effects.  
- Reference to SpaceX’s onboarding process: a new hire reported a database bug in HR software that delayed account creation, which was manually fixed so the engineer could start on Monday.  
- Link to TinyTapeout (https://mailchi.mp/574276e3c9d7/tinytapeout) – a low-cost efabless shuttle program that lets individuals fabricate 200–300-transistor designs on real silicon, discussed on Hacker News (https://news.ycombinator.com/item?id=32617620).  
- Brief confusion expressed about the purpose or value proposition of the Hyperbeam platform (https://hyperbeam.com/).