- Discussion of Sci-Hub donation safety: current working domains are .se and .st (with .se confirmed functional), and the suggestion that Sci-Hub maintainers should cryptographically sign donation instructions to prevent phishing.  
- Eric Drexler’s 2018 paper on “molecular imprinting” was shared (arXiv:1807.07065) as a route to programmable, atomically precise catalysts and molecular assemblers.  
- Exploration of ribosome-free peptide synthesis: cyclodipeptide synthases (CDPSs) were highlighted as an alternative to nonribosomal peptide synthetases, using aa-tRNAs to form cyclic dipeptides without ribosomes.  
- Recent review on evolving enzymatic electrochemistry by incorporating rare or unnatural amino acids to expand red-enzyme catalytic scope (Elsevier, 2022).  
- Presentation of synthetic de-novo protein catalysts that perform acyl-transfer reactions, documented in a French PhD thesis (tel-03499138).  
- Call for an “img2img for AlphaFold”: a tool that would let users sketch a 3-D structure and immediately obtain a compatible amino-acid sequence, akin to AlphaDesign (arXiv:2202.01079).  
- Survey of open-source AlphaFold accelerators: FastFold (GPU-cluster optimized) and Uni-Fold (33 000 GPU-hours training cost) were noted as community efforts to democratize structure prediction.  
- Nature Machine Intelligence paper on large language models for protein design, framing sequence generation as a text-generation task conditioned on structural prompts.