- A label-free, real-time assay for DNA/RNA polymerase activity was highlighted: electro-switchable gold-microelectrode biosurfaces that detect polymerase binding and base-pair extension via oscillating oligonucleotide probes, demonstrated with Taq and Klenow polymerases and compatible with off-the-shelf chips (Nature Scientific Reports 2016, https://www.nature.com/articles/srep12066).

- Montenegro’s Montelibero project was discussed as an agorist/libertarian enclave (~50 members) using an LLC-based immigration route (~100× cheaper than citizenship) followed by a five-year path to permanent residence, with the long-term goal of electing a parliamentary representative (requires ~6 000 citizens).

- Practical constraints on biohacking were detailed: Argentine customs block lab-supply imports, basic reagents like lye and sulfuric acid are regulated as “drug precursors,” and RV-based smuggling is a common workaround; synthetic ruby was noted as an unexpectedly available local material.

- The channel debated whether geopolitical instability is a legitimate topic for a “roadmap,” with one participant arguing that accurate threat models (e.g., 20 % chance of >1 million-dead US civil war within nine years) are necessary for transhumanist planning, while others insisted the focus should remain on science and technology.

- New transcript uploads were announced: Bryan Bishop added “Silicon Salon 2” materials covering Lightning-signer validation and precursor chemistry to the diyhpl.us wiki (https://diyhpl.us/wiki/transcripts/silicon-salon/precursor/).