- The channel debated whether to pursue hard-vacuum diamondoid nanotechnology or focus on aqueous-phase protein machines, with the latter seen as more immediately viable because functional protein nanostructures already exist in nature.  
- A near-term roadmap for low-cost protein synthesis was outlined: nanopores for drug delivery, catalytic membranes, virus-detecting antibodies, plaque-dissolving dental enzymes, AGE-cleaving enzymes for anti-aging, and intracellular trehalose for cryoprotection.  
- Participants explored printing spiroligomer monomers directly from amino acids as a biosynthetic route to solution-phase nanomachinery, referencing a Tetrahedron Letters paper on trans-4-hydroxy-L-proline precursors.  
- Subtractive diamond manufacturing was discussed, including protein-based fluorine/oxygen etching, two-photon selective etching, and the goal of mass-producing specific diamond parts at scale.  
- A central argument examined whether AGI could trigger a “FOOM” that accelerates atomically-precise manufacturing (APM) by 1,000,000×; skeptics cited physical bottlenecks such as thermal mass, unfavorable equilibria, and macroscopic reactor limits, while optimists pointed to MHz-rate AFM cantilevers and microsecond-cycle vacuum chambers as evidence that nanoscale processes can already operate millions of times faster than human-scale work.  
- The consensus emphasized that experimental feedback loops—rapid prototyping, model validation, and iterative design—remain the true bottleneck, and that better CAD/CAM, molecular-dynamics simulation, and automated lab tools (e.g., “Copilot-for-engineering”) are nearer-term accelerators than AGI.  
- A Nature Photonics paper on a chip-scale microcomb ring resonator achieving petabit-per-second optical data transmission was shared as an example of hardware whose switching speed already far exceeds human-scale processes.