- **AGI already exists (2021)**: maaku argues that large transformer models meet the original academic definition of AGI—domain-independent, unsupervised architectures capable of generalized problem solving and unrestricted knowledge transfer—and that adding agency is “literally 3 lines of Python” once value-alignment is ignored.

- **Transformer limitations noted**: Training is still offline/batch, so online one-shot learning is high-latency; the resulting agent would “work” but not think like a human.

- **Whisper.cpp port tested**: Georgi Gerganov’s open-source, CPU-only port of OpenAI Whisper runs locally; on non-AVX hardware it is ~16× slower than real-time and shows run-to-run variance in segmentation.

- **Longevity escape velocity (LEV) debated**: Participants question whether a sustained ≥1-year-life-extension-per-year trajectory is plausible; Kurzweil’s 2030 LEV prediction is cited as overly optimistic, while Metaculus gives only 50 % odds of any culturally significant aging breakthrough by 2030.

- **Germline vs. somatic enhancement**: kanzure notes that the most powerful longevity edits may initially benefit only future children; jrayhawk asks whether in-situ gene therapy can catch up within the 15–20 years it takes a child to mature.

- **Epigenetic aging reversal paper shared**: 2019 Fahy et al. thymus-regeneration study (Wiley *Aging Cell*) showing reversal of immunosenescent and epigenetic aging markers in humans.

- **Protein design breakthrough**: BioRxiv pre-print on integrating structure-prediction networks with diffusion generative models for “broadly applicable and accurate protein design.”

- **MeshCODE memory theory**: Eleanor Sheekey interview with Prof. Ben Goult proposing that the mechanosensitive protein Talin acts as an information-storage molecule linking extracellular-matrix stiffness to memory formation and age-related cognitive decline.

- **Xenotransplantation progress**: Review of 2021 NYU Langone pig-to-human kidney xenotransplant (α-gal knockout plus pig thymus co-transplant) with no immediate rejection; discussion of decellularized pig scaffolds seeded with human progenitor cells as a near-term organ-source strategy.

- **Documentary link**: *Make People Better* film site (https://makepeoplebetterfilm.com/) covering the He Jiankui gene-edited babies controversy and its ethical aftermath.