- ColabFold, a Google-Colab-based protein-folding pipeline, was shared as an accessible tool for running AlphaFold-style predictions without local GPUs.  
- Discussion of Adrian Bowyer’s “phaseshift” blog post questioned whether sub-wavelength antennas could emit coherent light; lsneff argued the antennas must be smaller than the wavelength or the output will split into multiple beams.  
- Elliot Hershberg’s tweets highlighted two distributed-biology initiatives: (1) Michael Jewett’s lab using cell-free protein synthesis to make peptide hormones at the point-of-care, potentially eliminating cold-chain logistics, and (2) BioNTech’s modular, shipping-container GMP factories for on-demand mRNA-vaccine production.  
- Participants debated the practicality of cell-free systems versus engineered tobacco or yeast; yashgaroth noted plants secrete poorly, lyophilizing ribosomes is hard, and regulatory-grade purity from E. coli lysates is unlikely without extensive QC.  
- Forgotten 1980s project “Leaf Protein International” was recalled: pilot data showed tobacco leaves yielding ~600 kg/hectare of crystalline food-grade protein, comparable to soy, but extraction and nicotine-removal costs were questioned.  
- Griffithsin, a red-algae lectin with broad-spectrum antiviral activity (HIV, coronaviruses), was revisited; literature suggests it could be a microbicide but may require de-immunization for chronic use.  
- Critique of “effective accelerationism” (e/acc): participants challenged the movement’s tangible output, contrasting it with EA’s documented (though debated) QALY-based charity evaluations and GiveWell-style impact spreadsheets.  
- Concerns over internet centralization: discussion tied Cloudflare’s gatekeeping to broader tiering of network access, with ASNs already functioning as de-facto “internet licenses.”  
- Forestry automation links showcased modern harvesters and mini-excavators clearing cut-over land, illustrating scalable mechanization for re-planting cycles.  
- A late-night aside invited deeper debate on cryonics revival—specifically the divergence between “physical” (biological repair) and “digital” (whole-brain emulation) pathways.