- The #hplusroadmap community launched a 15-year anniversary Discord experiment (invite: https://discord.gg/vFPzfaaeXv) to broaden participation in open-source transhumanist R&D.  
- Foresight Institute announced two upcoming events: a 24 Jan Molecular Machines talk by Christian Schafmeister on spiroligomer-based nanotech (https://foresight.org/technologies/nanotech-molecular-machines/) and a 27 Feb “Existential Hope Day” (https://foresight.org/foresight-existential-hope-day-2023/).  
- Discussion of “genomic landing pads” and a reusable gene-therapy “bootloader” concept: engineer cells with dummy viral receptors that can be hot-swapped to allow repeated, safe gene updates without immune rejection or over-expression.  
- Longevity links shared: Quanta article on ants extending lifespan 10× via altered insulin signaling (https://www.quantamagazine.org/ants-live-10-times-longer-by-altering-their-insulin-responses-20230110/) and a Reddit thread on CBP2-438GA as a human longevity target (https://www.reddit.com/r/Biohackers/comments/108ncxs/cbp2_438ga_as_a_target_for_extending_human/).  
- Cryonics & brain-preservation topics: request for room-temperature or 4 °C protocols; Synopticz pointed to the r/biostasis subreddit (https://www.reddit.com/r/biostasis) and Nectome transcript (https://diyhpl.us/wiki/transcripts/nectome-1517-2018/).  
- Debate on the “average human genome” proposal (attributed to Gregory Cochran) and the practicality of synthesizing a consensus genome free of rare deleterious mutations.  
- Microchimerism raised as a therapeutic strategy; docl suggested adding kill-switch apoptosis triggers to engineered cell lines to prevent immune dysregulation.  
- Concerns aired about societal backlash and potential bioterror targeting genetically modified humans, including speculation on stealth viral vectors that selectively harm “GMO” genotypes.  
- Andrej Karpathy’s new 2-hour tutorial “Let’s build GPT: from scratch, in code, spelled out” was circulated (https://www.youtube.com/watch?v=kCc8FmEb1nY).  
- OrionsArm.com announced a four-month collaborative world-building sprint focused on 30 km × 20 km orbital habitats, inviting ideas on internal systems and life different from planetary existence.