- A participant reported 10.5 years of 19-5 intermittent fasting, noting that adaptation took roughly six weeks and that no blood-work data were collected during the period.  
- Metformin was proposed as an adjunct to fasting; counter-arguments cited risks of indiscriminately suppressing oxidative stress and inflammation, with supporting links to PMC6351883 and an Oxford Academic article on hormesis.  
- Discussion on exercise aversion included pharmacological options: caffeine for lowering activation thresholds, amphetamines (and upcoming generic lisdexamfetamine) for stronger but riskier stimulation, and the open question of why most people intrinsically enjoy strenuous activity.  
- A suggestion was made to scale protein–protein interaction prediction to “all possible pairs,” referencing two recent preprints: one using protein language models (Nature Communications 2023) and another tweeted by luost26.  
- Vince Giuliano’s latest blog post, “Two Faces of Life Extension,” was shared as further reading on anti-aging strategies.