• A new ACS Nano Letters paper describes electrochemical 3-D printing at the nanoscale using quartz nanopipettes with openings as small as 1.6 nm; an automated feedback loop prevents nozzle clogging during electrodeposition.  
• Focused-ion-beam (FIB) trimming of glass nanopipettes was proposed as a scalable way to standardize tip geometry—coating the glass with carbon or gold makes it conductive for the ion beam, and plasma ashing or gold removal restores optical clarity.  
• Practical uses for sub-100 nm pipettes were discussed, including organelle-level patch-clamp recording (e.g., lysosome patch clamp from the Ren Lab at UPenn) and potential microinjection into single organelles.  
• Lilian Weng’s technical blog post on diffusion models (https://lilianweng.github.io/posts/2021-07-11-diffusion-models/) was shared as a reference for generative-model work.  
• A debate arose over the value of “news firehoses” versus curated weekly digests; participants argued that most daily or even weekly news is unreliable, and proposed summarizing primary sources (journals, IRC, direct project updates) instead.  
• Eric Drexler’s move from Oxford’s Future of Humanity Institute (Nick Bostrom’s group) to Astera was noted, with speculation about whether Drexler influenced Bostrom’s earlier advocacy of mass surveillance to mitigate existential risk.  
• Dental-health discussion linked plaque pathology more to immune status and fat-soluble vitamins (K2, A, D) than to mechanical brushing; Weston A. Price nutritional guidelines were cited for calcium homeostasis and epithelial integrity.