- Sam Zeloof’s startup AtomicSemi is exploring low-volume, rapid-prototype chip fabrication using single-beam e-beam lithography; participants argue that avoiding the cost and complexity of EUV or massively-parallel systems could let hobbyist-scale funding (e.g., Patreon) pay for “a few wafers a week,” while others note that arrays of cheap, independent e-beam columns or MEMS-based proton-beam tools might still scale if Coulomb repulsion and optics issues are solved.  
- A Nature paper reported that human cortical organoids transplanted into adult mice become vascularized, form human-mouse synapses, and show stimulus-evoked activity synchronized with host visual cortex, while a Cell Stem Cell study found similar organoids can restore visual function in rats after lesions—together suggesting that lab-grown neural tissue could serve as repair modules for brain injury.  
- DIY transhumanist wiki pages were updated with summaries of the ADRB1 and other short-sleeper gene variants linked to 4–6 h natural sleep with apparent cognitive benefits; discussion centered on why the trait remains rare despite a theoretical 5–10 extra waking years of “time-travel-enhanced” productivity.  
- Reservoir computing experiments were highlighted in which living neuronal cultures (“connectoids” and neurospheroids interfaced via microelectrode arrays) solve mazes and classify spoken digits, pointing toward hybrid biological processors that exploit the low energy cost of cultured neurons compared with large AI server farms.  
- Participants debated the true energy cost per query of ChatGPT versus human cognition, concluding that whole-body human metabolism (~10 MJ/day) and societal energy footprint (~200 MJ/day/person) currently dwarf AI inference, but engineered organisms such as fruit-fly or pygmy-frog neural cultures might approach theoretical minima.  
- Links collected include: OC.js (OpenCascade compiled to WebAssembly for browser CAD), Heidelberg Instruments’ thermal scanning-probe lithography, IMS multi-beam e-beam systems, and the OpenAI Startup Fund’s rumored investment in Zeloof/Keller’s chip venture.  
- A 2022 Tay-Sachs gene-therapy trial in two children was noted as a milestone for in-vivo CRISPR delivery, while broader discussion covered single-cell surgical techniques—electroporation, cytoplasmic transfer, CAR-T engraftment, and xenobot-guided cell fusion—as under-appreciated routes to enhancement.  
- Japan’s 2018 copyright amendment was cited: training-data mining and model adaptation are explicitly non-infringing if used solely for “data analysis,” potentially easing acquisition of large corpora for open-source AI projects.