- A new CRISPR-based method achieves targeted DNA integration in human cells without double-strand breaks by fusing RNA-guided Cas proteins with transposases (Nature 2023, biorxiv 2023.03.17.533036).  
- A PLOS Biology paper reports that hypothalamic expression of the scaffold protein menin regulates systemic aging and cognitive decline in mice, pointing to a druggable pathway for anti-aging interventions.  
- Two Nature papers describe inhalable nanoparticle formulations that deliver mRNA or achieve CRISPR gene editing in lung tissue, suggesting non-invasive routes for pulmonary gene therapy.  
- A Nature Biotechnology study demonstrates programmable protein delivery using a bacterial contractile injection system (synthetic phage-tail-like nanomachines), expanding the toolkit for cytosolic delivery of macromolecules.  
- Discussion of open-source, end-to-end encrypted video-conferencing tools: Jitsi Meet (WebRTC, FOSS server and F-Droid client) and Wire (higher security, also on F-Droid) were compared for usability and trust models.  
- Participants debated the feasibility and ethics of a global moratorium on AI training runs, with counter-arguments invoking the Streisand effect and the difficulty of enforcing bans against distributed research incentives.  
- Links to critiques of AI-doom narratives were shared, including Max More’s “Against AI Doomerism, for AI Progress” and historical reflections on the precautionary principle’s role in stifling beneficial technologies.  
- Several GitHub projects were highlighted that add autonomous agent loops around large language models—Auto-GPT, GPPPT (YAML DSL for multi-step LLM workflows), and LangChain’s memory-enabled agents—showing rapid open-source experimentation with LLM autonomy.