- A 2022 AI-Impacts survey of 738 recent NeurIPS/ICML authors found that >10 % of respondents believe “human inability to control future advanced AI systems causing human extinction” is at least a 10 % risk, prompting debate about sample bias between mainstream academics and “Yuddite” circles.  
- Bryan Johnson’s extreme longevity protocol—daily 4:30-5:30 am wake-ups, 8:30 pm bedtime, 5 % body-fat via caloric restriction, and dozens of tracked biomarkers—was highlighted as a real-time “lab rat” experiment for humanity, with discussion on whether discipline or biology is the limiting factor.  
- Participants questioned the micromort framework, arguing that equating one day of “doing nothing” with three skydives is misleading unless age-stratified actuarial data are used, and explored how the value of a day changes from age 10 to 100.  
- The channel revisited the 2018 CRISPR-baby controversy, noting that the He Jiankui YouTube channel is still online (688 k views on one video) and that the public email address dearluluandnana@gmail.com is receiving open letters ranging from rants to bio-art manifestos.  
- Cognitive stagnation in aging was framed as a possible biological exploitation-vs-exploration shift; psychedelic research and Lion’s Mane mushroom-induced neurogenesis were suggested as experimental levers to restore plasticity.  
- Microsoft’s HuggingGPT/JARVIS demo—letting ChatGPT orchestrate specialized Hugging Face models for multi-step tasks—was shared, alongside speculation that OpenAI may soon enable LoRA creation/sharing, raising concerns about Turing-complete LLMs with memory becoming security risks.