- Modos.tech showcased a working e-ink laptop and monitor prototype aimed at low-latency, eye-friendly computing; ideal refresh latency is 0–17 ms with a consistent < 120 ms in practice.  
- Discussion surfaced a 2007 Journal of Neuroscience paper on orexin/hypocretin as a potential “short-sleep” intervention, with participants noting its possible downstream role in modafinil’s wake-promoting effects.  
- Concerns were raised about long-term cognitive risks from chronic orexin use, citing a 2023 study in Neurobiology of Aging showing exacerbated deficits in Alzheimer’s model mice and possible glymphatic-system disruption in healthy adults.  
- Participants argued that orexin has still not entered human trials for narcolepsy despite current treatments being “dirty,” and that rigorous testing versus sleep-optimization hacks is warranted.  
- A patent for improved synthesis of lisdexamfetamine (US20120157706A1) was shared, hinting at DIY or open-source approaches to cognitive-enhancement compounds.  
- Hedgehog.app, a new project discussed with Bryan Johnson in Austin, was introduced via Twitter threads from its CTO (Colton) describing undisclosed but transhumanist-relevant technology.