• A 2022 study overturned conventional wisdom by showing that eccentric-only resistance training (assisted lift, single-arm lowering) yields the same strength and hypertrophy gains as full concentric-eccentric work, while blood-flow-restriction training further undermines the “micro-tear” theory by inducing growth via metabolic stress without damage.  
• Molecular-level insights: titin’s PEVK region acts as a mechanosensor—mice lacking 47 PEVK exons exhibited longitudinal hypertrophy through serial sarcomere addition, suggesting titin stiffness directly sets working sarcomere length and growth.  
• A technical roadmap for complete human sex conversion—combining in-vitro gametogenesis, cultured reproductive organs, and uterine transplantation—was judged technically feasible within 20–30 years, with regulatory and social barriers outweighing scientific hurdles.  
• Participants estimated that human-level compute will arrive within five years, but whether this produces aligned AGI or merely scaled-up narrow systems—and whether benefits reach non-billionaires—remains contentious; OpenAI’s public “Planning for AGI and beyond” post was cited as the closest thing to an official alignment plan, including eventual UBI exploration.  
• Practical AI use cases were demonstrated live: ChatGPT generated a working Unity C# scaffold for a Nethack clone, while a participant building an open-source six-axis bioprinter argued that manual R&D is still essential because current AI is “kind of an idiot” for specialized engineering and because manual work enlarges future training datasets.  
• The group framed “AI prepping” not as hoarding canned goods but as mastering existing AI tools, staying alive, and contributing open data/code so future systems inherit transparent, aligned knowledge bases.  
• Speculative futures included AI-generated transhumanist manifestos proposing sleep-abolishing neurostimulation for global scientific acceleration, synthetic “philosopher-guides” created from sleep-deprived human-AI hybrids, and interspecies governance councils with cetaceans and invasive species to co-manage Earth and communicate with extraterrestrials.  
• Labor-market disruption was highlighted by the AI-generated opening credits of Marvel’s “Secret Invasion,” cited as evidence that generative models already surpass amateur design work and are eliminating traditional animation jobs amid the WGA strike.