• Lion’s mane mushroom (Hericium erinaceus) was discussed as a potential neuro-regenerative agent; an oligosaccharide fraction is thought to act as a neurotrophic factor for repairing aging brains, although legality and anecdotal side-effect reports (r/LionsManeRecovery) were noted.

• The ethics and mechanics of pre-implantation genetic testing were debated: IVF embryos can be biopsied at the 8–32-cell blastocyst stage for whole-genome sequencing, enabling polygenic risk scoring for traits such as height and cognitive ability via GWAS-derived tools like those catalogued on SNPedia.

• Participants argued that simple embryo screening is ultimately limited by the finite genetic variation in a given cohort of embryos; instead, direct genetic engineering (introduction of large-effect edits) was proposed as the more powerful route to large cognitive or physical enhancements.

• High-dimensional tissue-imaging technique MIBI (Multiplexed Ion Beam Imaging) was introduced: it uses metal-tagged antibodies and secondary-ion mass spectrometry to obtain ~40-channel spatially resolved single-cell phenotyping without fluorophore spectral overlap, with example resources at angelolab.com.

• A conceptual thread explored “play anger” or transient, non-destructive anger as a motivational/educational tool, contrasting drill-instructor rhetoric, rap battles, and heavy-metal catharsis; the lack of a precise cultural vocabulary for this emotion was highlighted.

• The slow pace of novel psychedelic discovery was attributed to blanket prohibition and profit-structure disincentives, yet an extensive backlog of understudied compounds (e.g., 2C-B-NBOMe, bromo-dragonfly) exists as legislation slowly loosens for academic research.

• Ketamine and PCP were compared as NMDA-receptor antagonists: ketamine’s therapeutic, antidepressant potential and relatively benign safety profile were weighed against PCP’s stimulant-like, risk-laden behavioral effects, with references to MRI evidence of brain changes in chronic ketamine users.

• Links shared for further reading included Lockhart’s Lament on mathematics education, the Roots of Progress fellowship program, Einstein’s quest for unification (Cantor’s Paradise article), and Shulgin’s PiHKAL/TiHKAL as canonical psychedelic chemistry references.