• Ora, an early-stage longevity startup, is scaling nematode-based high-throughput screening to one million compounds per year to discover small-molecule anti-aging interventions, although participants debate the ~10 % mammalian-to-human translation rate of purely phenotypic screens.  
• DIY and open-source longevity strategies were contrasted: germline gene editing is considered technically easier than small-molecule discovery but faces FDA resistance and ethical objections, while epigenetic pulsed-drug protocols (e.g., entinostat + vismodegib to transiently open chromatin and clear senescent cells) were proposed as nearer-term testable alternatives.  
• Aubrey de Grey’s new LEV Foundation is reportedly pursuing “robust mouse regeneration” and down-playing Yamanaka-factor reprogramming; participants asked whether bulk stem-cell replacement or damage-repair remains the core plan.  
• Microfluidic organoid models were discussed as a route to higher-fidelity human-relevant drug testing; two review papers (PMID 35333271 and PMC8283929) were shared, alongside skepticism that microfluidics beats robotic pipetting for DIY labs.  
• A new molecular nanoengineering effort—aiming for sub-ångström precision mechanosynthesis beyond protein-based “bio-nanofactories”—was announced, with links to an open paper archive (diyhpl.us/~bryan/papers2/) covering longevity, microfluidics, AI, and neuro tech.  
• A Haskell prototype of a reflective oracle using Levin-search-style runtime bounding was released to explore corrigibility and decision-theory problems such as the “5-and-10” scenario, highlighting an open-source approach to AI safety distinct from mainstream “alignment” discourse.  
• Participants criticized the LessWrong/EA community for discouraging hands-on “capabilities” research and for cultural insularity, while endorsing Bayesian epistemology and debating the practical value of logical-induction frameworks and betting-market metaphors.  
• A 3-D-printing talk on parallelized slicing algorithms was accepted for Chaos Communication Camp 2023, continuing the channel’s tradition of open-source hardware contributions.  
• Science magazine’s cover story on whole-organ cryopreservation (https://www.science.org/content/article/how-to-deep-freeze-entire-organ-bring-it-back-to-life) was circulated as a sign of progress toward reversible organ banking.