• A new Science paper (10.1126/science.adf8009) shows that many individual bone lengths are highly heritable, prompting discussion of whether growth-hormone or SNP-based interventions could override these genetic constraints.

• Digicortex v2—an open-source, GPU-accelerated large-scale spiking-neural-network simulator—was announced after roughly a decade of development (video link: https://www.youtube.com/watch?v=XyUU0RNonKE).

• A DARPA-funded project to build computer chips that integrate living human-brain organoids received military backing; related links to recent papers on vascularized brain organoids were shared in the 14 July log archive.

• Participants debated “Humans 2.0” design goals: instead of (or in addition to) myostatin inhibition, they considered increasing myonuclear density to create a built-in “muscle-memory” buffer against famine or supply-chain collapse.

• Bimagrumab—a monoclonal antibody that blocks activin/myostatin receptors—was highlighted as an upcoming weight-loss drug that spares muscle; projected cost is $20–30 k yr⁻¹ until manufacturing scales.

• Cardiac safety of chronic myostatin inhibition was discussed: evidence suggests hypertrophy is minimal unless myostatin is knocked out from birth, and titin-length modulation was floated as an alternative target.

• Long-term food-security scenarios were analyzed: Haber-Bosch nitrogen (≈1 % of natural-gas use), phosphate rock mining bottlenecks, potassium extraction from seawater via solar-driven recrystallization, and the fragility of global fertilizer and diesel supply chains.

• Open-source memes were invoked—comparing resilient agriculture to self-hosting Linux—to argue that modular, low-tech process heat (e.g., solar thermal) and open hardware could localize fertilizer production if global logistics degrade.

• Spiroligomer-based synthetic membranes (Wiley, DOI: 10.1002/ange.202302809) were noted as a near-term lab reality for “nanotech-level” filtration without full molecular assemblers.

• James Harrison, the 1,173-unit blood-plasma donor with anti-Rh antibodies, was cited as a longevity case study; participants mused about ultra-high-resolution solar imaging as a metaphor for enhanced human vision.