- David Dalrymple’s WBE Workshop 2023 talk “Rethinking Uploading Given 10-Year AI Timelines” (13 min YouTube) was circulated as evidence that whole-brain emulation could be feasible within a decade if current AI scaling trends continue.  
- Participants debated the philosophical legitimacy of destructive versus non-destructive uploading, with one contributor stating they would accept a 50 % merged identity but not a post-upload termination of the biological original.  
- The conversation framed the fear of “losing oneself” as a residual belief in non-material identity, prompting pushback that a simple desire for continued subjective experience is not equivalent to belief in ghosts or souls.  
- L29Ah proposed leveraging generative “AI” for “clean-room” reverse engineering of proprietary systems, arguing that model-generated code may slip past copyright restrictions and accelerate open-source liberation of commercial technologies.  
- docl highlighted a Proto.life article on a startup engineering rice to grow at full oceanic salinity (32 g L⁻¹), noting current prototypes already thrive at 16 g L⁻¹ and the genetic pathway to double salt tolerance is understood.  
- fenn linked the Nature paper “Platelet factors attenuate inflammation and rescue cognition in ageing” (2023), identifying platelet factor 4 (PF4/CXCL4) and its receptor CXCR3 as key mediators of young-blood cognitive rejuvenation in mice.  
- Discussion cautioned that PF4-based therapies treat downstream inflammatory symptoms rather than root aging mechanisms, and clarified that platelets are cellular components, not plasma fractions, complicating “young plasma” narratives.  
- Proto.life was praised as a valuable aggregator of emerging biotech news, despite clickbait headlines such as “Will my dog get precision medicine before me?” and coverage of cultured-meat salmon nigiri.