- Eliezer Yudkowsky’s recent Twitter thread on “ribosomes” (https://twitter.com/ESYudkowsky/status/1695871950852403415) is interpreted by participants as an abstract argument that future nanofactory self-replication mechanisms will look very different from biological ribosomes—likely using wheels or other non-biochemical architectures.

- Critics argue MIRI/LessWrong abandoned the only practically useful AI-safety directions (corrigibility, stop-button problems) in favor of “agent foundations” and endless re-hashing of Bayesian epistemology; Cartesian frames are praised as an interesting alternative to Pearlian causality.

- A blog on deriving online-learning rules with “mutable variables” (https://shaoweilin.github.io/) is highlighted as an example of philosophy-flavored work that yields concrete, elegant mathematical results linking predictive coding and RL via surprisal minimization.

- Discussion of cognitive decline in a post-COVID heart-failure patient (male, early 50s) centers on possible hypoxia from lowered blood-pressure medication; practical diagnostics (inflammation panel, $100 pulse-ox, sleep-apnea screening) and interventions (Tai Chi, near-IR or hyperbaric oxygen, piracetam-class nootropics) are suggested.

- Long-term demographic speculation: “printing” genetically engineered humans could create either monocultures of superhumans or, conversely, unprecedented variance via horizontal gene transfer and sampling across the tree of life; participants urge early linguistic separation of “person” vs “human” to handle future value and communication gaps.

- A new open-source project, “fidget” (https://github.com/mkeeter/fidget), is dropped without elaboration.

- DoD “bioradar” for biosurveillance is flagged as a topic of interest (tweet link: https://twitter.com/matt_f_mcknight/status/1696114455631765969).