• A 2022 human pilot (n=8) demonstrated broad rejuvenation biomarkers after therapeutic plasma dilution via plasmapheresis, yet the procedure remains under-funded and hard to access off-label despite its low risk profile (doi:10.1007/s11357-022-00645-w).

• Channel participants explored building a DIY plasmapheresis rig from standard parts (blood pump, centrifuge/membrane separator, anticoagulant, return line), identifying clotting as the chief safety concern and noting a price arbitrage: commercial anti-aging clinics charge ~US $6 000 while plasma-donation centers perform the same physical procedure for free or even pay the donor.

• Senolytic drugs such as Fisetin and Navitoclax were debated: although they clear senescent cells in rodents, members questioned systemic ablation due to poor bioavailability, pro-cancer risks of exogenous antioxidants, and the need for targeted delivery (e.g., galacto-conjugated Navitoclax).

• Stem cells, PRP, HBOC, NIR/PBM, and other non-pharmaceutical modalities were highlighted as potentially powerful yet under-studied because they are difficult to patent and therefore attract little commercial R&D investment.

• A Chinese study reportedly isolated a Lactobacillus strain that ferments pomegranate ellagic acid into the longevity metabolite Urolithin A, but the strain identifier was withheld, blocking replication and illustrating the reproducibility challenges in open-source longevity research.

• New mouse data indicate that normal dietary aspartame can cause heritable cognitive deficits, while the low-calorie sweetener Allulose was proposed as a safer alternative, underscoring the need for caution with “safe” food additives.

• A YouTube lecture on bioelectric morphogenesis (youtu.be/41b254BcMJM) showed that precise modulation of voltage-gated ion channels alone can induce extra limbs in frogs, suggesting regenerative-medicine strategies that bypass genetic engineering.

• Ted Chiang’s short story “Understand” was cited as a plausible cognitive-enhancement scenario in which controlled neuro-regrowth after massive brain injury surpasses baseline human intelligence, framing neuro-regeneration as a path to transhuman capability.