- A post titled “Biomedical Progress” (https://markov.bio/biomedical-progress/) was circulated; it argues that Eroom’s-law-driven declines in pharma ROI can be reversed by replacing traditional discovery pipelines with AI-driven screening and human organoid models.  
- Docl floated a speculative “nucleus-replacement” architecture for eukaryotic cells: an artificial mRNA-synthesis module that continuously emits custom transcripts to keep the cell specialized and self-repairing, eliminating most native gene-regulation machinery.  
- Discussion followed on whether such a system could bypass the normal differentiation cascade; kanzure noted that direct protein/peptide injection is an alternative, while L29Ah warned that recapitulating the full differentiation program would still be non-trivial.  
- A lattice-based SSH vulnerability was highlighted (Schneier post: https://www.schneier.com/blog/archives/2023/11/new-ssh-vulnerability.html) in which passive network attackers can recover RSA host keys by exploiting naturally occurring signature-calculation faults.  
- Kanzure shared a link to the “VX Underground Collection” HDD—an offline archive of malware samples sold as a physical drive (https://www.vx-underwear.org/products/vx-underground-collection-hdd).  
- Fenn pointed to an upcoming early-Friday Starship launch and posted a 3-D-printed “companion cube” image intended as an emotional-support robot (https://fennetic.net/sd/companion_cube2.jpg).