- Latest MMLU 5-shot benchmark scores were compared: GPT-4 leads at 86 %, followed by Gemini Ultra 84 %, Inflection-2 79 %, Claude-2 78 %, Grok-1 73 %, Gemini-Pro 72 %, GPT-3.5 70 %, and Llama-2 68 %; the highest score among open-weights models is 78 %.  
- A Nature paper (s41586-023-06800-3) was highlighted showing that N1-methylpseudouridine modification in mRNA vaccines (e.g., BNT162b2) causes +1 ribosomal frameshifting in vitro and triggers cellular immunity to the frameshifted products in mice and humans.  
- Discussion of longevity interventions included rapamycin studies and a shared NIH link (PMC7238909) on NMN (nicotinamide mononucleotide) supplementation.  
- Mistral AI released “Mixtral-8x7B,” an 8×7 B mixture-of-experts model with 32 k context length; the magnet link for the torrent was circulated, noting it should fit into a 24 GB GPU once quantized.  
- Additional links shared: Bloomberg opinion piece on gene-editing trends, the “Maintenance of Everything” book chapter on precision manufacturing, and the startup Ohalogenetics.