- Participants questioned the reliability of cryonics, noting that “natural causes” on death certificates is a legal placeholder rather than a medical explanation and lamenting the absence of reputable cryonics organizations.  
- A cost-benefit comparison of vitamin-D sources found 400 × 10 kIU soft-gels on Amazon (~$10) equivalent to 10 kIU-per-drop vegan liquid from Vitabay, but highlighted label ambiguities in concentration.  
- Discussion of vitamin-A, D, and K interactions emphasized that retinoids and vitamin-D form heterodimers for immune and calcium regulation, while menatetrenone (vitamin-K2) is required for calcium management, and typical industrial diets are insufficient in all three.  
- Debate over beta-carotene versus pre-formed vitamin-A: Eli argued evolutionary conservation makes carotene safe for most, while jrayhawk cited SNP data showing up to 45 % of humans are poor converters and that “highly conserved pathway” claims are misleading.  
- Anecdotal evidence was shared of 50 000 IU vitamin-A plus 12 000 IU vitamin-D daily resolving ovarian cysts without surgery, aligning with Weston A. Price Foundation recommendations of a 4–8:1 A:D ratio.  
- Participants discussed using high-dose retinol instead of isotretinoin for acne, noting similar pharmacodynamics but a two-order-of-magnitude cost difference and less regulatory friction.  
- Eli proposed FDA reforms to remove efficacy mandates and allow patients to self-prescribe stable long-term medications (e.g., unchanged eyeglass or drug scripts) to reduce gate-keeping costs.  
- Caloric restriction lifespan controversy: Ashstar claimed universal life-extension across species, while jrayhawk countered with murine studies showing genetic variation can shorten lifespan under restriction and human RCT evidence is absent.  
- Vitalia.city announced a 2-month “pop-up city” on Roatán (Jan 6 – Mar 1 2024) dedicated to making “death optional,” framed as an experiment in longevity-focused community building.