• A new open-source Streamlit app called AgeRank (agerank.streamlit.app) is compiling every known aging biomarker and visualizing how each changes with chronological age, aiming to replace “black-box marketing ploys” with a transparent, filterable database for researchers and experimenters.

• Community members highlighted non-neuro-inspired algorithms that mirror biological processes, including ant-colony/pheromone routing, genetic algorithms, particle-swarm and “bees” algorithms, reaction–diffusion systems, L-systems, P-systems, and even analogies between file-sharing and bacterial conjugation.

• Dr. Michael Lustgarten’s YouTube channel (@conqueragingordietrying1797) was cited as a model of open, self-experimentation: he repeatedly measures aging biomarkers, adjusts one variable at a time, and publicly reports side-effects and null results—especially during his NAD-pathway supplementation trials.

• A rare SERPINE1 loss-of-function mutation found in an Amish cohort is linked to ~10 % longer lifespan and telomeres; a small-molecule SERPINE1 inhibitor has now entered Phase 2 human trials (ScienceAlert coverage shared).

• Discussion of “choosing the right parents” included ApoA-I Milano, Italian CVD-resistant villagers, and Inuit & Maasai genetic adaptations to high saturated-fat diets, with debate over whether protection is genetic or dietary.

• Corticosteroid-induced mood changes were explored: clinicians call acute mood elevation “the Remicade high,” while 5–18 % of patients develop corticosteroid-induced psychosis, supporting the “sickness-behavior theory of depression” rooted in inflammatory over-reaction.

• Bio-inspired construction ideas emerged—using swarms of small robots with soft McKibben “air-muscle” actuators to emulate mud-dauber wasps, which build complex, curved mud structures without rigid scaffolding or precise measurement.

• Bamboo was evaluated as a structural material: Guadua angustifolia offers the best mechanical properties for building, while Phyllostachys edulis (moso) and black-stemmed Phyllostachys nigra were compared for growth speed and cold tolerance.

• Links and references shared include Weston Price’s “Nutrition and Physical Degeneration,” the Rejuvenation Olympics longevity leaderboard, a PMC review on body-temperature modulation of aging, and the Yi Visual Language Model (6 B/34 B LLaVA variants) for multimodal AI.