• A participant warned that the much-cited Valproate “adult neuroplasticity” study is over-hyped: small n, liver-toxic drug, unknown mechanism—future work should isolate the MOA (likely HDAC inhibition) and design a cleaner compound.

• Extended critique of Eliezer Yudkowsky-style AI-risk quantification: precise Bayesian probabilities are meaningless when the underlying variables cannot be measured, and MIRI’s focus on theoretical decision theory (UDT) diverted resources from practical safety research.

• Discussion of engineered oral microbes: Lantern Bioworks’ anti-caries strain was noted, and a new proposal floated for a bacterium that selectively degrades dental calculus (tartar) without harming enamel, with Porphyromonas gingivalis identified as the key periodontitis pathogen to outcompete.

• Roatan “Próspera” libertarian charter city came under skeptical scrutiny—questioning whether importing Western tech and legal outsourcing to Honduras truly embodies anarcho-libertarian ideals.

• Link to a Nature paper on promoting natural tooth repair with small-molecule GSK3 antagonists (e.g., Tideglusib) that stimulate dentine regrowth was shared.

• Open-source AI tools highlighted: Open Interpreter (LLM-driven computer control), Rawdog (natural-language to Python interpreter), and vision-language models for GUI automation.

• A brief exchange on PDE5 inhibitors (sildenafil, tadalafil) and potential cognitive effects via increased cerebral blood flow and cGMP signaling was prompted by a GPT-4 query.

• Spreadsheet-style “rationalist” morality memes (quantifying relationships, trading partners like assets) were roundly criticized as culturally hazardous pseudo-rigor.

• Practical decision-making under bounded rationality was emphasized: strategy trees must account for real-world computation costs and time constraints, not infinite Bayesian updates.