- A Nature Aging paper identifies plasma proteins GFAP, NEFL, GDF15 and LTBP2 as the strongest early blood-based predictors of all-cause dementia, Alzheimer’s disease and vascular dementia, offering potential low-cost screening biomarkers.  
- Discussion of scarce hardcopies of key transhumanist texts: “KSRM” (presumably K. Eric Drexler’s Nanosystems) and the “bunny book” (likely Feynman’s Lectures on Computation) are out of print; “Advanced Automation for Space Missions” is also hard to find, prompting suggestions to set eBay alerts.  
- A new participant asked for community nootropic stacks and mind/body enhancement protocols; the group consensus was to optimize sleep, diet and exercise before pharmacology, and to involve knowledgeable physicians for interventions such as trans-cranial magnetic stimulation (TMS).  
- A Twitter thread on ASML’s extreme-ultraviolet lithography systems was dissected: the company relies on ~5 000 suppliers, 20 M lines of code with no automated tests, and senior-only code ownership—cited as a pre-SpaceX “large-systems-integrator” model ripe for vertical-integration disruption.  
- Lifespan.io’s paid anti-death essay “Why Death Is Bad” by Patrick Linden was linked; members debated its claim that longevity-driven population growth is negligible if fertility stays near replacement, with counter-arguments that zero mortality would still yield linear growth and that Japan’s rural “free house” programs reflect economic stagnation, not under-population.