• A new transgenic cow engineered to secrete human insulin in milk is discussed as a route to ultra-cheap insulin production, with the linked press release at https://www.sciencedaily.com/releases/2024/03/240313135347.htm.

• Participants debate the feasibility and ethics of using somatic-cell nuclear transfer (cloning) to propagate beneficial human traits, noting that genomic imprinting errors remain a major epigenetic hurdle; a PNAS paper on dCas9-Dnmt3a-Dnmt3L targeted methylation (https://www.pnas.org/doi/pdf/10.1073/pnas.2115248119) is offered as a possible fix.

• Embryo splitting—mechanically dividing an early embryo to create genetically identical twins—is highlighted as a legally distinct alternative to nuclear-transfer cloning; the 1993 Hall et al. human-embryo splitting experiment and subsequent destruction of data are cited, along with the observation that most national “anti-cloning” laws do not explicitly ban embryo splitting.

• DIY longevity pharmacology is reviewed: metformin is argued to blunt muscle hypertrophy and may be counter-productive in non-diabetics, while rapamycin is considered promising if dosed intermittently to minimize immune suppression; the Interventions Testing Program (ITP) is said to lack funding for definitive human studies.

• Practical sugar-control hacks mentioned include Lily’s sugar-substitute chocolate as a “methadone for sugar addiction” and the broader point that large muscle mass is protective against sarcopenia-related falls in aging.

• A wiki update on genetic modifications for preventing wisdom-tooth eruption is noted (http://diyhpl.us/diyhpluswiki/genetic-modifications/), with frustration expressed that literature focuses on disease-causing mutations rather than beneficial “supernormal” phenotypes.