- A new review article on “Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations” was shared, highlighting how large-scale sequencing is refining our understanding of age-related somatic mutation rates and their heritable components.  
- The Effective Altruism Global conference in Austin (EAGxAustin 2024) was announced, with participants noting its heavy focus on AI safety, bioethics, and skepticism toward advanced nuclear reactors.  
- A working proof-of-concept exploit for the recently discovered xz-utils backdoor (CVE-2024-3094) was circulated, underscoring supply-chain security concerns for open-source infrastructure.  
- A community member asked whether anyone had completed the full fast.ai course, implicitly seeking feedback on its utility for self-directed AI and bioinformatics work.  
- A debate on the epistemics of altruistic investment broke out: participants questioned how EA funders (e.g., GiveWell) determine comparative ROI between fields such as cancer research versus AI research, emphasizing the high opportunity cost of mis-allocation.  
- Bryan Bishop published a freshly transcribed talk by Johnny Anomaly on embryo selection, covering polygenic scoring, ethical trade-offs, and policy implications; the transcript is now archived at diyhpl.us/wiki/transcripts/2024-04-02-johnny-anomaly-embryo-selection/.