• A new Science paper reports the spontaneous formation of extraterrestrial peptides and their derivatives under space-like conditions, expanding hypotheses about abiogenesis and panspermia (https://www.science.org/doi/10.1126/sciadv.adj7179).

• Profluent released “OpenCRISPR,” an AI-designed Cas9 variant claimed to cut DNA more precisely and with fewer off-target effects; the underlying model was trained on a newly curated CRISPR-Cas Atlas of 5.1 million proteins, a 2.7× expansion of known natural diversity (https://www.biorxiv.org/content/10.1101/2024.04.22.590591v1).

• Community discussion of dementia interventions: fasting plus serine supplementation may help clear BMAA (a neurotoxic algal amino acid); turmeric/curcumin, intermittent ketosis, B-vitamins, DHA, rapamycin-induced autophagy, therapeutic plasma exchange, and pollution reduction were all cited as potentially useful tactics.

• Bryan Johnson published self-experiment data showing a 160 % rise in follistatin after minicircle gene therapy; David Ishee shared a year-long follow-up with even higher follistatin levels, prompting debate on dosing and safety (https://www.rapamycin.news/uploads/short-url/jlJjB748AdNFUJQSMj7dSeROC5i.pdf).

• NASA bed-rest studies were highlighted as empirical evidence that long-term immobilization causes measurable structural brain changes, feeding into the broader debate on whether human minds are “fundamentally embodied” or could be sustained as disembodied emulations.

• Participants emphasized practical indoor-air interventions: high-efficiency particulate filters, always using stove vents, and avoiding indoor combustion sources like toasters; real-time PM2.5 data is available via https://fire.airnow.gov/ and https://earth.nullschool.net/.

• The channel mocked “responsible biodesign” initiatives as re-hashing gun-control rhetoric, while half-seriously proposing “irresponsible” projects such as proteins that self-assemble into chess pieces or mine Dogecoin in vivo.