• Laura Deming’s new cryonics startup Cradle (cradle.xyz) claims the first recovery of electrical activity (action potentials) in cryopreserved and rewarmed rodent neural tissue, and has raised ~$48 M; skeptics note that small-scale cryopreservation already existed and question what justifies the large funding.  
• A February 2024 pre-print (bioRxiv 2023.01.04.522507v2) reports systemic AAV delivery of an inducible OSK (Yamanaka minus c-MYC) gene therapy that extended median remaining lifespan of 124-week-old mice by 109 % while improving frailty scores, providing the first in-vivo evidence that partial reprogramming can safely rejuvenate whole organisms without immediate tumorigenesis.  
• Discussion emphasized shifting longevity research from “small-molecule miracle drugs” and marginal lifespan extensions to programmatic interventions that directly reverse root aging mechanisms and improve measurable health-span biomarkers.  
• Rational trigonometry—a finitist, real-number-free reformulation of trigonometry—was cited as an example of “no upper limit” mathematics that can still find practical application in robotics and control systems.  
• Participants recommended using high-fidelity simulation as the first step in robotics development: “If you can’t get it to work in sim, it’s going to be even more difficult IRL.”