- **Peplica patent reverse-translation workflow**: fenn used Claude to decode an “obfuscated” patent on protein reverse translation (Peplica) and posted the AI-generated summary at https://fennetic.net/irc/protein_reverse_translation_peplica_explained_by_claude.html, highlighting a practical use of LLMs for navigating dense biotech IP.

- **Klotho, platelet factor 4, and cognitive enhancement**: Eli shared a new video update (https://youtu.be/qsA5MBLoeGI) summarizing recent findings that klotho and platelet factor 4 mediate exercise-induced cognitive benefits, with Mendelian-randomization evidence that klotho variants protect against APOE4-related decline.

- **Cross-species validation of klotho pathway**: the discussion noted supporting mouse and even primate dose-response studies, underscoring translational momentum for klotho-based therapeutics and the need for increased funding in this area.