- A participant reported that even low-dose (5–10 mg) dextroamphetamine taken at 8 a.m. produced such long-lasting stimulation that it repeatedly disrupted sleep, leading them to abandon the prescription entirely.  
- The Foresight Nanotech Tree (https://foresight.org/ext/ForesightNanotechTree/) was shared as a curated map of nanotechnology pathways; users noted its omission of spiroligomer chemistry and suggested it may still contain useful literature references.  
- A 2020 talk by C. Schafmeister, “Hardware and Software of a Critical Path to Bottom-up Molecular Nanotechnology” (https://www.youtube.com/watch?v=yQ09nW8UhU4), was highlighted as essential viewing for understanding spiroligomer-based approaches to atomically precise manufacturing.  
- Discussion centered on whether glutaraldehyde-induced protein cross-links—being less specific than glucosepane cross-links—could ever be enzymatically reversed; the consensus was that many specialized spiroligomer enzymes might be required, but their smaller size relative to natural proteins could make the task more feasible.  
- The ISAAA’s global GMO approval database (https://www.isaaa.org/gmapprovaldatabase/) was linked as a resource for tracking which genetically modified crops are legally cultivated in different countries.  
- A Substack essay titled “ICE: The Penultimate Frontier” (https://transhumanaxiology.substack.com/p/ice-the-penultimate-frontier) sparked brainstorming about building artificial ice continents at a fraction of the stated $20 M/km² cost.  
- One proposed low-cost method involves spraying seawater into cold, dry air to precipitate salt-contaminated snow; under the right temperature regime the salt would selectively melt ice, drain away as brine, and leave behind inexpensive, self-reinforcing ice platforms without expensive desalination.