- A newly-published mouse study (PMID 39020175) reports that late-life inhibition of the cytokine IL-11 extends median lifespan by >20 % in both sexes, while also reducing age-related cancers and preserving muscle mass.  
- Participants questioned whether such large benefits could be “side-effect-free,” invoking antagonistic pleiotropy and noting that IL-11 is required for wound healing, collagen production, platelet-driven clotting, and STAT3-mediated tissue regeneration.  
- Concerns were raised that chronic IL-11 blockade might impair resistance to infectious disease or fat storage, suggesting the intervention could trade longevity for increased vulnerability to trauma or infection.  
- The discussion compared anti-IL-11 therapy favorably to lifelong caloric restriction, calling for replication in additional mouse strains, other organisms, and at different treatment ages to confirm the effect size and safety profile.  
- A link to the open longevity-interventions wiki (http://diyhpl.us/diyhpluswiki/longevity/interventions/) was added to archive the findings and related references for the community.