- A pre-print on “3D-Imaging of synapses in neuronal tissues with synchrotron X-ray ptychography” was shared, offering a label-free, high-resolution method to map synaptic ultrastructure in intact brain tissue.  
- Lifespan.io coverage of a study showing that partial cellular-reprogramming (OSK factors) restored cognitive performance in aged rats was circulated, reinforcing interest in epigenetic rejuvenation strategies.  
- Discussion of rapamycin’s potential to extend female reproductive lifespan by ~5 years via ovarian aging delay; participants noted current efforts to test pulsed-dosing regimens that might retain benefits while minimizing mTOR-related side effects.  
- Skepticism was voiced about David Sinclair’s research program, with one participant arguing that his work should be disregarded until independent groups demonstrate practical, reproducible applications.  
- A link to “AI Snake Oil: AI Existential Risk Probabilities” was posted, inviting scrutiny of quantitative x-risk estimates and the assumptions behind them.  
- Eliezer Yudkowsky’s tweet thread was relayed in which he reported that GLP-1 agonists (Ozempic/Mounjaro) failed to help him manage weight without continued prolonged fasting, prompting broader commentary on individual variability in anti-obesity pharmacology.