- Debated whether Eliezer Yudkowsky’s past “peak performance” claims were tied to deliberate calorie-overfeeding; the only public statement found was that he avoids cognitive impairment from calorie deficit rather than claiming overeating boosts intelligence.  
- Explored the idea of repurposing plasma-apheresis machines for repeated, same-day lipoprotein/fat removal as a cheaper, safer alternative to liposuction; concluded circulating lipids are mostly cholesterol esters and fatty acids transported in lipoproteins, not bulk “fat”.  
- Discussed hypothalamic regulation of adipose mass via leptin sensitivity and inflammatory cytokines (IL-6, TNF-α); removing lipids or cytokines without fixing underlying inflammation merely triggers compensatory appetite or lean-mass loss.  
- Proposed a speculative evolutionary-pressure hypothesis: certain gut-microbe strains or biofilms may benefit from host obesity and therefore up-regulate appetite; considered targeted narrow-spectrum antibiotics, monoclonal antibodies, or delayed-release probiotic + biofilm-disruptor pills as counter-measures.  
- Reviewed practical dietary interventions: evaluate food on immunological safety, oxidative stability, micronutrient density and bioavailability rather than rely on drugs or surgery; noted semaglutide as a recent pharma success that still risks lean-mass loss.  
- Linked background reading: Cleveland Clinic explainer on lipoprotein structure, Diabetes journal review on hypothalamic inflammation, and a Manifold prediction market on gut-microbe-driven obesity mechanisms.  
- Shared Facebook’s July 2024 announcement advocating open-source AI as “the path forward” (https://about.fb.com/news/2024/07/open-source-ai-is-the-path-forward/).