• BHT (butylated hydroxytoluene) was re-examined as both a food-grade antioxidant for protecting lipids during cooking and, per Steven Fowkes’ 2020 book, as a potential antiviral supplement against chronic viral infections.  
• The mitochondrial theory of aging was challenged: same-sex parent–child lifespan correlations do not strongly implicate mtDNA as the sole driver, and aging is better modeled as a network-level degradation process rather than a single-gene or organelle failure.  
• Germline intervention was framed as the highest-leverage route to radical life extension, with proposals ranging from 500-year human breeding programs to accelerated mouse embryo-selection via IVF plus whole-genome sequencing.  
• Partial cellular reprogramming with Yamanaka factors (OSK) shows promise—mouse retinal studies restore vision—but teratoma risk, dosage control, and the danger of erasing identity-critical memories in post-mitotic neurons remain unsolved.  
• A “Theseus-style” brain-refresh protocol was outlined: iteratively ablate the least-active 10 % of neurons, stimulate regrowth, and use dreaming to re-train new cells, aiming to preserve learned function while gradually replacing aged tissue.  
• Current adult gene-therapy vectors were deemed inadequate; mesenchymal stem cells and engineered T-cells were suggested as lower-immunogenic “Trojan horses” for multiplex edits or therapeutic payloads.  
• Long-term transhumanist trajectories include abandoning biology for solid-state or nanotech substrates, with interim steps such as graphene-nanoribbon “DNA tape” synthetic nuclei, spiroligomer enzymes, and rice-grain-sized cellular factories to replace mitosis.  
• Evolutionary arguments hold that humans are “programmed to die” because selection pressure collapses after reproduction; antagonistic pleiotropy and negligible post-reproductive fitness benefits explain finite lifespan.  
• The anti-aging field was criticized for over-emphasizing small-molecule supplements and short-term adult interventions; instead, advocates should prepare society for a 200–350-year research horizon and prioritize germline or whole-body replacement strategies.  
• Shared resources included the Bitcoin Transcripts archive, Nature papers on Drosophila lifespan extension via PRC2 modulation, and technical notes on singular learning theory (SLT) for understanding neural-network generalization.