• Jean Hébert (new ARPA-H hire) is expected to launch a major program on “functional brain tissue replacement,” aiming to add youthful neural tissue to aging brains, as described in the book “Replacing Aging.”  
• The blood–brain barrier’s limited permeability was debated: alonzoc suggested viral vectors (e.g., rabies-like tropism) could enable organ-wide gene editing, while jrayhawk noted chemokine-induced endothelial permeability can open the BBB and that neuroinflammation in MS, Alzheimer’s and Huntington’s is already addressable via metabolic and chemokine modulation.  
• Donanemab gained FDA approval for Alzheimer’s despite lingering skepticism about the amyloid-clearing mechanism; NIH statement provided for context.  
• Open-source longevity roadmap released by Long Bio Fellowship (longbiofellowship.org/roadmap) and a 2023 paper (PubMed 36829757) were circulated as strategic resources for radical life-extension research.  
• Podcast-search tool PodScan.fm and transcript-replication project btctranscripts.com (described as “replicating Bryan Bishop”) were highlighted as new OSINT and archival technologies.  
• DIY biomaterials discussion: docl is culturing kombucha mats on paper, perlite and even urine to create low-cost, low-odor insulation or sanitation products, critiquing the expense of mammalian-cell bioreactors.  
• Industrial-biotech brainstorming covered turning urea into ammonium nitrate, cellulose-to-keratin pathways, nitrogen-fixing bacteria, and a ScienceDirect paper on 100 % bio-based nylons from lignocellulose.  
• Follistatin’s potential effects on tendon development and scar-tissue prevention were raised as a follow-up to myostatin-inhibition discussions.  
• Debate on feasibility of Drexlerian nanotech: fenn mocked a six-page EA essay expressing despair over enzyme-to-nanofactory scaling, countering that enzyme “meat-men” could bootstrap diamondoid tools and that supply-chain objections are overblown.