- A participant (NewtonTrendy) proposed that DNA methylation levels are not merely reset but are actively maintained or increased when telomeres remain sufficiently long, suggesting that youthful telomere length may directly sustain epigenetic youthfulness.  
- The same contributor argued that observed methylation changes after CRISPR-based rejuvenation treatments are driven by shifts in “epigenomic age” rather than by a failure to reset methylation marks, and emphasized that iterative, imperfect interventions could still be valuable instead of waiting for a single perfect solution.  
- Discussion of brain organoid models noted that the current cultures are “small organoids” lacking vascularization, highlighting a current limitation for scaling or long-term viability of in-vitro neural systems.  
- A Science paper was shared describing a newly discovered mechanism in which bacteriophages trigger reverse transcription to assemble a toxic, repetitive gene from a non-coding RNA, illustrating an unexpected pathway for phage-mediated gene regulation and potential synthetic-biology applications (DOI: 10.1126/science.adq3977).