- Jacob Hanna’s lab achieved “complete human day-14 post-implantation embryo models from naive ES cells” in 2023, only one year after demonstrating the same milestone in mice, prompting debate about why success appears rapid despite many labs and companies (Ivy Natal, Conception Bio, Gametogen, Dioseve, Hojo, OvaScience, etc.) pursuing similar goals.

- The critical bottleneck is not generating the embryo itself but producing “healthy enough” naive ESCs—low mutational load, robust mitochondrial health, and proper epigenetic state—before ethically creating a baby; large-scale embryo selection (10,000+ embryos) is viewed as the nearer-term benefit.

- A Bay-Area biotech fire-sale at Hound Labs (Fremont, CA) is liquidating substantial open-hardware lab equipment: −80 °C freezers, incubators, centrifuges, Epilog laser cutters, biosafety cabinets, fume hoods, chemicals, and more, with an open-house at 9 am.

- A new Nature paper describes “multi-pass, single-molecule nanopore reading of long protein strands,” offering a potential path to high-accuracy proteomic sequencing; a Phys.org article on magnetic nanotech for safe cryo-rewarming was also shared.

- Discussion of Richard Feynman’s “bottom-up” nanotechnology path (“Where is My Flying Car?”) prompted a query about current groups explicitly attempting the Feynman route.