- AI systems have now defeated traffic-image CAPTCHAs, marking another milestone in machine-vision capabilities and raising questions about the continued viability of CAPTCHA-based human verification (Ars Technica article shared).  
- A new paper on “Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism” was highlighted, with the suggestion that direct PGC-1α overexpression experiments should be pursued to test metabolic enhancement strategies.  
- Discussion referenced a UCLA Health article revisiting the controversial 2002 Women’s Health Initiative hormone-replacement therapy (HRT) study, noting ongoing criticism of its methodology and conclusions and its impact on transhumanist longevity and hormone-optimization research.  
- A tweet thread by @KillenMd (linked via x.com) was circulated, though its specific content was not summarized in the log; it appears relevant to current biohacking or medical debates.  
- Brief mention was made that “Montana mountain king” received a six-month prison sentence, implying legal repercussions for an individual or project within the community, though details were not provided.