- A new Markov.bio research post outlines a mechanistic-interpretability roadmap for achieving end-to-end biological design using AI, framing biology as a programmable substrate analogous to neural networks.  
- A proposed therapy for type 1 diabetes involves reprogramming adipocytes (fat cells) into insulin-producing cells, offering a potentially autologous and minimally invasive alternative to pancreatic islet transplants.  
- The Linux Foundation has abruptly decommissioned its public mailing-list infrastructure (lists.linuxfoundation.org), signaling a retreat from open email-based community governance and prompting discussion about sustainable open-source communication platforms.  
- A gist and Twitter thread (kanzure/4e7bcc58344ceaa1a668e65a434adb2b and x.com/kanzure/status/1853630334161592742) compile recent links and commentary on open-source transhumanist projects, though specific content is not quoted in the log.  
- A white paper from Bia-Echo argues that extending female reproductive longevity is “low-hanging fruit” for health-span interventions, summarizing evidence that ovarian aging is tractably modifiable compared with other aspects of systemic aging.