- Google Cloud’s Threat Intelligence team published a deep-dive on “Scatterbrain,” a new obfuscation framework used by the PoisonPlug threat actor, highlighting evolving malware tradecraft.  
- A Nature paper demonstrates whole Drosophila-brain imaging at nanoscale resolution via potassium-acrylate expansion microscopy, offering a scalable route to high-resolution connectomics.  
- BioRxiv preprint reports the first single-AAV CRISPR editing of skeletal muscle in non-human primates using “NanoCas,” an ultracompact Cas variant that fits inside one viral vector.  
- Science article describes an engineered system that triggers recombination between human repeat elements to randomize the genome—framed as an early step toward a minimal human genome.  
- Channel participants debate hashcash-style proof-of-work for email anti-spam, concluding that CPU-cost thresholds fail because legitimate users value their time more than spammers value CPU cycles, and power-law “whale” victims keep spam profitable.  
- Discussion extends to attaching digital cash to email: if a universal currency existed, recipients could refund friendly mail, reducing net cost to zero; SMS-verified accounts currently serve as the de-facto scarce token.  
- Atomic Machines, a stealth-mode startup pursuing the “Waldo path” to molecular nanotechnology, is noted; positions are nominally grad-level but the group encourages direct outreach from interested engineers.  
- Open Medical Reasoning Tasks (GitHub: openlifescience-ai) is shared as an open dataset/benchmark for evaluating large language models on clinical reasoning.  
- Participants weigh the coming disruption of medical AI: likely launch in doctor-scarce developing countries, expansion driven by cost pressure, and the argument that AI can outperform humans on differential diagnosis and bedside manner if error rates are rigorously quantified.  
- News links detail the “Zizian” saga—an erstwhile transhumanist community member allegedly faked death in 2022 and is now wanted in multiple U.S. states in connection with homicides, prompting cautionary remarks about ideological radicalization.