- **ADHD stimulant absorption vs. pH**: Participants discussed how many amphetamine-based ADHD medications (e.g., Adderall) form insoluble salts with weak organic acids, sharply reducing absorption; acidic foods or supplements (juice, soda, vitamin C, fortified cereals, etc.) should be avoided within ±1 h of dosing.  
- **Drug-specific exceptions**: Lisdexamfetamine (Vyvanse) and methylphenidate (Concerta) appear largely unaffected by gastric pH, according to FDA prescribing information and a cited PK study (PMC6544597).  
- **Mechanistic details**: Two distinct pH effects were noted—gastric/intestinal pH lowering absorption, and urinary acidification increasing renal excretion—each potentially altering net bioavailability in opposite directions.  
- **Sources shared**: Links exchanged include an archived clinician hand-out (nw-adhd.com PDF), a physician’s table of “Agents Impairing GI Absorption,” and the official Adderall and Vyvanse prescribing inserts.  
- **Josiah Zayner’s new venture**: A brief mention that biohacker Josiah Zayner is now working on “building unicorns” via the project/website https://building.life (exact technical details not elaborated).