- A new pre-print on “protein deimmunization” describes computational methods to redesign therapeutic proteins so they evade immune detection, a key step toward safer gene and enzyme therapies.  
- Cerebras’ Wafer-Scale Engine (WSE) is reported to achieve one million molecular-dynamics time-steps per second, enabling ~0.1 ms of simulation per day for 100k–1 M atom systems, though current limitations exclude explicit treatment of bonded molecules.  
- The efabless/TinyTapeout open-source shuttle program is winding down; TinyTapeout-11 closes for submissions within days, and the community is scrambling to finalize last-minute chip designs before the service disappears.  
- A “sequencing by expansion” technique, outlined in another pre-print, proposes using polymer swelling to transduce nucleotide identity into optical signals, potentially offering a low-cost, high-throughput alternative to current sequencing chemistries.  
- Discussion on the #hplusroadmap wiki raised concerns over Wikipedia’s “New eugenics” article, which has been heavily edited to cast the topic in a negative light; participants debate whether to distance transhumanist reproductive technologies from the term “eugenics” or to reclaim and clarify it.