• The term “3-D genome change” was clarified to mean the physical 3-D conformation of DNA in the nucleus, not merely epigenetic marks such as methylation or acetylation.

• A request for high-quality sources on “longevity denial” (a.k.a. the “pro-aging trance”) led to the Wikipedia article on the topic and a 2012 meta-analysis of calorie-restriction studies in rodents (PMC3476836) being offered as evidence of widespread misrepresentation in the longevity industry.

• Discussion of the calorie-restriction evidence concluded that CR shows inconsistent lifespan extension even in short-lived rodents and has not been demonstrated in humans; Ramadan was cited as an observational but non-randomized human example.

• Strong skepticism was voiced toward the SENS research program, with the analogy that its strategy is “putting the horses back in the barn while the doors are open and the horses are on fire,” implying that SENS targets downstream damage without addressing root causes.

• Ethical and psychological debate arose over labeling the choice to accept aging and death as “suicidal” or “psychotic,” with counter-arguments emphasizing autonomy, death anxiety, and the social burden of suicidal individuals.

• A brief note on gender differences linked to death anxiety referenced the Wikipedia section “Death anxiety § Sex” as a possible explanatory factor for longevity asymmetry between sexes.