• A ketogenic diet appears to resolve one individual’s non-24-hour circadian rhythm disorder, while a fat-free rice-and-marinara diet re-triggered it—raising the possibility that macronutrient ratios modulate melatonin synthesis via BH4-dependent pathways and choline/Apo-lipoprotein dynamics.

• Participants debated the reliability of longitudinal food-frequency questionnaires versus grocery-store receipts as dietary data sources; LLMs were proposed as a way to parse receipt-level detail into quantitative nutrient profiles, but thermal-paper BPA exposure was flagged as a practical barrier.

• The need for a real-time, interactive “cyberspace interface” to the human metabolome was repeatedly emphasized—participants surveyed existing tools (Reactome, KEGG, Escher, Metabolic Atlas, iPath3, BRENDA) and criticized them for static diagrams, missing quantitative parameters, and poor chemical-structure integration.

• A Nature paper (s41467-024-47527-7) was highlighted in which human keratinocytes injected into a fetal mouse womb engrafted and produced humanized skin, spurring discussion on interspecies complementation and chimeric organ generation.

• A Technology Review article on “ethically sourced spare human bodies” triggered debate over legalizing organ markets; concerns centered on perverse incentives, while exitbid.com was offered as an example of an open marketplace for end-of-life assets.

• Eli noted that even heavily studied pathways and blockbuster drugs often have mechanisms as vague as “Mars in retrograde,” underscoring the gap between curated pathway diagrams and real-world biological variability.

• A SXSW company offering 500-analyte blood metabolomics panels was cited as evidence that systems-biology-scale data could soon distinguish healthy versus diseased metabolic states, despite current replication crises in basic research.

• RangerMauve volunteered to prototype a 3-D, hierarchical graph-navigation system for metabolic networks, framing it as a multi-year UX and graph-transformation project.