- Reverse-translation of proteins into nucleic acids (a “reverse ribosome”) was proposed: an enzyme that unfolds a target protein in vivo and ligates trinucleotides according to the peptide sequence, possibly using AI-designed “inverse-tRNAs”; patents and start-ups (Encodia, Glyphic, Quantum-Si) plus nanopore protein-sequencing projects were linked as prior art.  
- Discussion of open-source microfluidics and electrowetting hardware resurfaced, with links to Hackteria-style DIY cartridges and a Mondrian microfluidic chip paper.  
- Progressive brain-tissue replacement as a longevity strategy was critiqued: the idea of injecting stem cells plus embedded electronics was questioned for feasibility, especially how long-range axons/dendrites could be preserved; a speculative “space-filling intracellular parasite” was floated as a scaffold.  
- A call for “controllable nanomachines” that let bioengineers steer single molecules in real time with laser-controlled conformational changes was circulated (kakamatech@gmail.com), alongside a “whole neuron project” aiming to map every molecule in a neuron with spatial context.  
- Debate on formal verification of Bitcoin consensus: participants concluded that a rigorous, neutral, formally verifiable specification is probably impossible without first soft-forking to a formally definable script subset; tools mentioned include K Framework, CBMC, ESBMC, SMACK, and incremental migration to dependent-type languages like Idris.  
- AI-driven medical diagnosis economics: $10 k/patient cost in the MAI-DxO study was clarified as diagnostic-test cost, not token spend; Eli argued global demand will come from regions lacking doctors and eventually pressure Western adoption.  
- Identity/IQ verification online without government involvement was brainstormed: proposals ranged from offline certificate authorities and Worldcoin-like hardware orbs to polygenic IQ scores, Web-of-Trust p2p assertions, and calculus-based CAPTCHA replacements.  
- Links to DARPA’s spin-controlled chemical process engineering program, aerosolized H5N1 gain-of-function research video, Foldit’s current AlphaFold integration, and a cyberpunk techno-opera album were shared.