- Fenbendazole’s anti-cancer mechanism: it starves tumors by down-regulating GLUT transporters and Hexokinase II, while also triggering mitochondrial p53 translocation; prostate cancers may prefer fat over glucose, complicating ketogenic-diet strategies.  
- Engineered-adipocyte cancer therapy: implantable adipocytes engineered to secrete anti-tumor factors suppress tumor growth in mice but fail on high-fat diets; implants are fully removable and leave no residual organoids (Nature Biotechnology 2024).  
- Glutamine-targeting drugs: 6-Diazo-5-oxo-L-norleucine and its prodrug JHU-083 act as glutamine antagonists that covalently inhibit glutamine-utilizing enzymes in cancer cells.  
- Hyperthermia for early respiratory infections: discussion of designing a distributed clinical trial using controlled core-temperature elevation (hot-water immersion preferred over saunas or hair-dryer air) to treat common colds; blinding and patient recruitment remain unsolved.  
- HIV-vaccine frustration: 40+ years without a cure or effective vaccine; RV144 trial showed 43 % protection via IgG against V2 loop but 54 % increased risk with IgA; newer ideas include codon-modified HIV that requires an unnatural amino acid to replicate.  
- IRB legitimacy crisis: He Jiankui’s gene-edited babies case used to argue that revocable ethics approvals undermine the social contract; if committees can retroactively disavow approvals, ethical review becomes meaningless and drives researchers away from formal oversight.  
- Libre-SoC funding collapse: grant terminated amid unclear medical and administrative issues; successor project “libre-chip” continues work on an open-source, spectre-resistant speculative processor architecture with formal verification.  
- Browser tab management debate: participants weigh keyboard-driven window managers vs. Chrome’s tab search; Firefox’s URL-bar tab switching noted, but performance depends on browser-compositor cooperation.  
- Macroeconomic view of “hodling”: hoarding crypto increases others’ purchasing power, yet deflationary spirals can reduce investment in useful human endeavors and amplify liquidity shocks.