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07:19 <@kanzure> "Brain Corporation receives Series B funding from Qualcomm Ventures and signs a multi-year R&D agreement with Qualcomm Incorporated to develop a spiking model of the motor control system."
07:20 <@kanzure> "The funding will allow Brain Corporation to scale up to 40 scientists -- all experts in neuroscience of sensory and motor processing. The goal is to create the greatest and the most advance computational neuroscience group under one roof."
07:24 <@kanzure> http://www.scholarpedia.org/article/Scholarpedia:2012_Brain_Corporation_Prize_in_Computational_Neuroscience
07:27 <@kanzure> http://www.scholarpedia.org/article/User:Bryan_Bishop/Proposed/Generating_realistic_neuron_morphology_to_inform_and_test_scanning_and_connectomics_initatives
07:27 <@kanzure> well it seems i have to be a "world-class expert" that they already know in order to be approved
07:27 <@kanzure> so, fuck that
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07:30 < archels> Izhikevich isn't a stranger to some self-inflation.
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07:40 <@kanzure> archels: screw 'em
07:40 <@kanzure> qr code fail http://news.ycombinator.com/item?id=4570216
07:41 <@kanzure> "Maybe they got the idea from Google Code, which helpfully shows me a QR code for the tarball I'm about to download, for all those times I'm using the browser on my desktop and the IDE on my phone."
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07:47 <@kanzure> http://blogs.bmj.com/bmj/2012/07/03/richard-smith-medical-journals-a-gaggle-of-golden-geese/
07:47 <@kanzure> "According to the editor of the British Medical Journal, Dr. Richard Smith, 'The major journals try to counterbalance the might of the pharmaceutical industry, but it is an unequal battle -- not least because the journals themselves profit from publishing studies funded by the industry."
07:47 <@kanzure> "According to Dr. Smith, this can amount to more than $1 million for a single article. At the same time that medical journals are given incentives to please the drug companies, they are also given strong disincentives to go against drug company interests. According to Dr. Marcia Angell, former editor of NEJM, editors of medical journals exercise self-censorship -- trying to avoid offending their chief advertisers, the drug companies."
07:49 < foucist_> kanzure: i'm sure the brain corp will need programmers
07:50 < Mariu> corporation ?
07:53 < Mariu> nevermind :p it's corporation I guess =]
07:53 -!- mode/##hplusroadmap [-b klafka!*@*] by kanzure
07:59 < foucist_> Mariu: yeah,pretty standard contraction i think
07:59 < Mariu> foucist: got it
08:15 < archels> Can anyone access this PDF? www.crcnetbase.com/doi/pdf/10.1201/NOE0415380416.ch63
08:16 < Mariu> Poromechanics III - Biot Centennial (1905-2005):; Numerical aspects of multiionic transport in electrolytic solutions 2005 (access for 72 hours for US $20.00)
08:17 < Mariu> not really, no
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08:40 <@kanzure> oh yessssssz
08:40 <@kanzure> http://ieeelog.com/
08:40 <@kanzure> ieee passwords
08:41 <@kanzure> " ftp://ftp.ieee.org/uploads/akamai/ (closed on September 24 around 13:00 UTC, after I reported it).  "
08:41 <@kanzure> fuck that guy
08:42 < Mariu> :o
08:42 <@kanzure> "However, I did not, and plan not to release the raw log data to anyone else"
08:43 <@kanzure> noooooo
08:43 < chris_99> heh
08:43 <@kanzure> he is the worst
08:44 <@kanzure> juul: can you get one of your posse to go steal his logs? i'm sure it's on a laptop somewhere in his house
08:45 < Mariu> =]
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09:17 < skorket> hey kanzure, do you have anything in your archives about non-engineered lateral gene transfer?
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10:27 <@kanzure> skorket: http://diyhpl.us/~bryan/papers2/bio/ComP,%20a%20pilin-like%20protein%20essential%20for%20natural%20competence%20in%20Acinetobacter%20sp%20strain%20BD413%20-%20regulation,%20modification%20and%20cellular%20localization.pdf
10:27 <@kanzure> http://diyhpl.us/~bryan/papers2/bio/Genetic%20transformation%20in%20freshwater%20-%20Escherichia%20coli%20is%20able%20to%20develop%20natural%20competence.pdf
10:28 <@kanzure> http://diyhpl.us/~bryan/papers2/natural_competence.txt
10:31 < skorket> thanks
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11:18 <@kanzure> http://www.glassdoor.com/Reviews/Makerbot-Reviews-E480203.htm
11:24 < skorket> Bre Pettis == Steve Jobs?
11:25 <@kanzure> unlikely.
11:25 <@kanzure> lots of people think they are steve jobs
11:25 <@kanzure> none of them are.
11:25 <@kanzure> http://www.openbiotech.com/
11:25 <@kanzure> "Ultimately, we anticipate no less than an industry-wide collapse of biological reagent pricing as a direct result of our open source policies."
11:26 <@kanzure> i don't understand. are their sequences any different from other sequences? are their proteins special for some reason?
11:28 < Urchin[Emacs]> Steve Jobs was good at making cults, at least
11:29 < Urchin[Emacs]> it looks like here it's simply that the product makes a cult all by itself
11:29 <@kanzure> what product?
11:29 < Urchin[Emacs]> makerbot
11:29 < Urchin[Emacs]> of course
11:29 <@kanzure> ok what cult?
11:29 <@kanzure> i think you're talking out of your ass, i'm just trying to get you to explain yourself
11:30 < Urchin[Emacs]> you mean about Steve Jobs?
11:30 < Urchin[Emacs]> sorry, this is a bit too confusing
11:30 <@kanzure> about bre pettis.
11:30 <@kanzure> bre is just some guy. he's not steve.
11:31 < skorket> steve was some guy before he was steve.  Not saying he is, but he's making a product that seems to have a large following.  He has a store in NYC.  He's cognisant of style.  And he apparently has a huge ego too
11:31 <@kanzure> i also have a low opinion of steve jobs
11:31 < Mariu> sweet
11:32 < Mariu> especially after that speech of his
11:32 <@kanzure> but, as low of steve as i think, bre just doesn't match his skill
11:34 < delinquentme> ^
11:35 < Urchin[Emacs]> I have a very low opinion of Steve Jobs, and I consider him mostly as a new age cult leader who hapened to be working with computers for a time
11:37 <@kanzure> the compulsion to try to compare people to steve jobs is very strange to me
11:40 < Urchin[Emacs]> I don't find it all that strange
11:40 < Urchin[Emacs]> and I don't have a strong opinion about it
11:47 <@kanzure> perhaps you should get one
11:50 <@kanzure> "The IEEE is an association, and doesn't actually have any engineers working for it."
11:50 <@kanzure> this amuses me
11:52 < Urchin[Emacs]> lol
12:09 <@kanzure> ftp://ftp.wiley.com/public/journals/jcc/suppmat/readme.txt
12:11 <@kanzure> http://www.benthamscience.com/
12:11 <@kanzure> oops
12:11 <@kanzure> ftp://ftp.benthamscience.com/pub/
12:12 < strangewarp> Steve Jobs made computers the way that people who don't know about computers wanted computers to be.
12:12 < strangewarp> So of course he's an idol to them.
12:12 <@kanzure> ftp://ftp.acs.org/acsbooks/
12:13 <@kanzure> hah
12:13 <@kanzure> ftp://ftp.acs.org/windows/Office%202010%20Professional/
12:14 <@kanzure> ftp://ftp.acs.org/pub/outgoing/careers/
12:15 <@kanzure> ftp://ftp.acs.org/pub/incoming/shadow
12:15 < Mariu> strangewarp, well said !
12:16 <@kanzure> ftp://ftp.acs.org/pub/mem/mem_retention/ACS%20Renewal%20Counts%20Feb%2009.xls
12:19 <@kanzure> ftp://ftp.aip.org/
12:23 <@kanzure> this lists 'passwd' as a file. just saying. ftp://ftp.aip.org/etc/
12:26 <@kanzure> ftp://ftp.elsevier.com/elsevier-out/
12:26 < Mokbortolan_1> PSA: http://blogs.computerworld.com/malware-and-vulnerabilities/21056/another-critical-java-vulnerability-puts-1-billion-users-risk
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12:59 < strangewarp> Hm. I wonder how far away we are from 3D-printed potentiometers.
13:00 < strangewarp> Actually.. huh. You could probably make a simple slide pot pretty easily, if you installed the contacts and resistive substance yourself..
13:07 < chris_99> they print carbon resistors on PCBs although that's not the same
13:07 < strangewarp> Yeah, those are a pain in the ass to replace when they wear out, though
13:09 < chris_99> didn't know resistors did wear out tbh
13:10 < strangewarp> Oh, sorry, they print carbon potentiometer-sliders onto PCBs as well
13:10 < strangewarp> Sorry, my mind collapsed "resistor" and "potentiometer" into the same category there :p
13:10 < chris_99> ah heh
13:11 < strangewarp> Newer low-end electronic music gear will just have its sliders incorporated into the case, and sliding cross a carbon film that's been printed onto the PCB
13:11 < strangewarp> This is why companies like Behringer will just send you a replacement mixer, instead of repairing your old one, when one of the sliders wears out
13:12 < strangewarp> Since I'm not dums, I bought a Mackie, and it's likely to last me until I'm either famous or dead :3
13:13 < strangewarp> but yeah, 3D-printing poetntiometers might be surprisingly easy, hm
13:13 < strangewarp> ..poet'ntiometers.. yes fine
13:14 < chris_99> i find it interesting that the 'reprap' is called a replicating printer
13:14 < chris_99> when the majority of it needs to be bought
13:14 <@kanzure> adrian hopes it will be one day self-replicating
13:14 <@kanzure> but yes i agree that it was prematurely named replicating
13:15 < strangewarp> yeah, that always struck me as overly optimistic marketing that could backfire
13:15 <@kanzure> "oh it can print its own plastic parts!" that's cool and all, but those aren't the interesting parts.
13:21 <@kanzure> http://en.wikipedia.org/wiki/Tokyo_Gore_Police
13:26 < strangewarp> Plot synopsis is.. interesting
13:32 < delinquentme> random: anyone happen to know how long it takes for concrete to soft set?  I've got a mold i poured it into and I'm wondering how long it will take before I can pull the sides of the mold off
13:32 < delinquentme> also working w concrete is for the birds
13:35 <@kanzure> 3 hours
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14:56 <@kanzure> so what's this about maradydd getting a castle
15:01 < jrayhawk> no fair i want a castle
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16:45 < alusion> Good evening gentlemen
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17:45 <@kanzure> "The second is derived from the biopunk movement in which people create synthetic biology using DIYbio. In this context, biohacking refers to mixing and matching genes and characteristics from different species."
17:45 <@kanzure> wikipedia is awful
17:47 < yashgaroth> baaaaaah
17:47 < yashgaroth> also feh
17:47 <@kanzure> who the hell wrote that? i bet it was that dave assey fellow that jrayhawk likes so much
17:47 < yashgaroth> heh...assey
17:47 < yashgaroth> anyway what's wrong with calling it 'bodyhacking'?
17:48 <@kanzure> because that doesn't help their personal brands
17:48 <@kanzure> http://en.wikipedia.org/wiki/Biohacking
17:48 <@kanzure> feel free to edit the fuck out of that
17:50 <@kanzure> and for references:
17:51 < yashgaroth> I need to find out who changed genetic engineering to the "second" and beat them mercilessly...editing is for suckas
17:51 <@kanzure> http://diyhpl.us/wiki/diybio/faq/news
17:51 <@kanzure> yeah, i don't know how they think that's acceptable at all
17:51 <@kanzure> tim ferris? give me a break
17:52 < yashgaroth> "Brianhkerr", you're about get an ass-whoopin'
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17:55 < yashgaroth> I might as well give it up and just use biopunk instead...or biofunk, but that sounds like it smells bad
17:55 <@kanzure> it *does* smell bad
17:55 < brownies> biojazz
17:56 < brownies> evolution is just improvisation, baby!
17:56 < yashgaroth> I *do* love reefers
17:57 < yashgaroth> maybe I can call it biofuckallyall so people won't put it in books about fucking fad diets or however biohacking gets used these days
17:59 <@kanzure> good plan
18:00 <@kanzure> "Brianhkerr (talk | contribs)‎ . . (2,063 bytes) (+541)‎ . . (Added Brian Kerr - added sf chronicle links and notation. Changed order of meanings to reflect the most common use first.) (undo)"
18:00 <@kanzure> oh i see
18:00 <@kanzure> yeah, that's not biased. -_-
18:01 < yashgaroth> lemme go nmap his ISP and backtrace his packets with a for loop
18:02 < yashgaroth> ...haskell
18:03 <@kanzure> "DNA synthesis is already less than a penny per 50 bases, using DNA from chips based on our 2004 Nature paper.
18:03 <@kanzure> (Some rich labs still pay 2000 times that amount per base even for large projects 8 years later)."
18:03 <@kanzure> " LS9 has moved well such beyond research to industrial scale oil-producing bacteria factory in Florida.
18:03 <@kanzure> http://www.industrialinfo.com/showAbstract.jsp?newsitemID=228784 "
18:06 <@kanzure> "He claims to have shaved 20 years off his biochemistry and increased his IQ by as much as 40 points through 'smart pills', diet and biology-enhancing gadgets."
18:06 <@kanzure> i increased my iq 200 points.
18:07 < ParahSailin_> what a complete fruitbat
18:07 < yashgaroth> biology-enhancing gadgets? like he uses the internet to solve IQ tests?
18:07 <@kanzure> sigh
18:07 <@kanzure> i can't believe people buy that
18:07 <@kanzure> well, yes i can. but i can't that wikipedia allows it.
18:09 < brownies> kanzure: what the goddamn fuck? where is that from?
18:09 <@kanzure> wikipedia bro
18:09 <@kanzure> http://en.wikipedia.org/wiki/Biohacking
18:09 < brownies> well, i guess it is prefaced with "He claims"
18:09 < brownies> i could claim some stupid shit too, i guess.
18:09 <@kanzure> who cares what he claims
18:09 < brownies> oh, fucking Dave Asprey
18:09 < brownies> i read his blog, and bought his coffee beans
18:09 <@kanzure> why...
18:09 < brownies> most disgusting coffee i've ever tasted
18:10 <@kanzure> this is why you guys should stop reading blogs
18:10 < brownies> well, i needed to buy coffee beans anyway, so i was like "oh, i guess his look magical"
18:10 < brownies> so... i bought some magic beans... and they turned out to be worthless.
18:10 < brownies> when i put it that way, i sound like a real idiot. -_-
18:11 <@kanzure> it's okay. marketing strikes when you least expect it.
18:11 <@kanzure> i typed in my email address in a box in 2009 and i've regretted it ever since.
18:11 < brownies> haha.
18:11 < brownies> this wikipedia article doesn't even have periods on the ends of the sentences.
18:11 <@kanzure> bioperiods..... or maybe not
18:12 < yashgaroth> eww
18:12 < yashgaroth> Brian Henning Kerr, author of "QuantifiedScience.com" AHA
18:12 <@kanzure> do these people take themselves seriously?
18:13 < yashgaroth> is there some clause in wikipedia about pimping your own fucking blog?
18:13 <@kanzure> most def
18:13 < yashgaroth> to the revert room!
18:13 <@kanzure> i think it all needs to be reverted
18:14 <@kanzure> even if tim ferris has a legit claim about takling about it, i don't think that should be the focus of the article.
18:14 <@kanzure> *talking
18:15 <@kanzure> also, if biohacking is going to end up with self-promoting assholes, i want out
18:16 < alusion> Do any of ya'll have a blog?
18:16 < alusion> Also is kanzure a spin-off from cancer? xD
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18:17 < alusion> ಠ‿ರೃ
18:17 -!- mode/##hplusroadmap [+o yashgaroth] by kanzure
18:17 -!- mode/##hplusroadmap [+o brownies] by kanzure
18:20 <@yashgaroth> "@Brianhkerr #Lifehacker, #Biohacker, and Knowledge Mongerer. Tennis playing, Tea Drinker, Thinker" wow that south park episode about SF was true, no offense to our SF people
18:21 < alusion> So you know how different frequencies have different effects on the mind and our behavior / mood?
18:21 <@kanzure> fuck dude, go away
18:21 < alusion> What's your problem?
18:22 < alusion> Serious question, you seem to be here 24/7 and everytime I want to talk you seem to have a cactus up your ass and the red flags already flared
18:22 < docl> alusion: he isn't tuned in on an optimal frequency yet. send him some good vibes.
18:23 < alusion> Sorry you're right
18:23 < alusion> I find it enjoyable, I like his spunk
18:23 <@kanzure> jrayhawk: https://www.startssl.com/ eh?
18:23 < alusion> I just want some intelligent conversation :\
18:23 <@kanzure> alusion: you're an idiot and can't remember our first conversation
18:23 <@yashgaroth> then try being intelligent Oooooh sick burn
18:24 < alusion> I remember you got pissed off about my retro encabulator
18:24 < docl> so, um, frequencies. you mean like brainwaves?
18:25 < alusion> I meant external frequencies
18:25 <@kanzure> "And of course, we now have evidence that educated users practice superior computer security; compare "1234" (the most popular password among the general populace) to "123456" (the most popular password among IEEE members). That's at least 50% more secure!"
18:25 < Mariu> lol
18:25 < docl> alusion: brainwave entrainment stuff?
18:26 < docl> alusion: or you mean color? or sound?
18:26 < alusion> No like, you heard of the experiment they did with prisoners where they would shoot different frequencies and they had a receiver wired up to certain parts of the cranium or something, and studied behavior patterns and the like.
18:27 < alusion> Basically showing how different frequencies can have different effects, would you like me to find the study before continuing so I may base off some sauce?
18:28 < alusion> I would imagine ya'll to be already aware of such programs though =\
18:28 <@yashgaroth> I think you'd better had
18:28 < ParahSailin_> i keep my facebook password set to 123456
18:28 <@kanzure> ParahSailin_: that's the only way to be sure
18:29 < ParahSailin_> people keep changing it, so every time someone sends me a link i have to open in facebook, i have to reset it back
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18:40 <@kanzure> lessawful
18:40 <@kanzure> lesslikepukeinmymouth
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18:58 <@brownies> ooh... check out my fancy hat
18:58 <@brownies> so, who was it here that was experimenting with piracetam?
18:59 < strangewarp> I was doing aniracetam but now I'm doing noopept/Cognizin
19:00 <@brownies> noopept is too mysterious and not well-studied enough for me
19:00 <@brownies> it *sounds* nice, but... just not enough data.
19:00 < strangewarp> Yeah, I'm still considering whether to continue with noopept after I run out of what I currently have
19:01 < strangewarp> (120 capsules from Brainpower Nutriceuticals)
19:02 <@brownies> why? how do you like it? how long have you been taking it?
19:02 <@brownies> heh, sorry for the inquisition... can't help it
19:02 < strangewarp> It's working well, like a very strong version of aniracetam, which makes sense
19:03 < strangewarp> It hasn't necessarily helped my notoriouxly lax work ethic, but it's like an ultra antidepressant, an order of magnitude more reliable than SSRIs
19:04 <@brownies> i see
19:05 <@brownies> why'd you pick aniracetam over piracetam, btw?
19:05 < strangewarp> Arbitrary reasons, I guess
19:05 <@brownies> afaict piracetam seems to be the usual starting point
19:05 <@brownies> ah ok
19:06 < strangewarp> I may respond to nootropics by becoming only marginally more productive, but way, way less depressed
19:06  * strangewarp shrug
19:09 < strangewarp> So basically I'm doomed to taking them every day now, or else I will be the same horribly depressed person I used to be, which kind of sucks
19:09 < strangewarp> but whatever
19:11 <@brownies> strangewarp: i see
19:19 < strangewarp> I have noticed that after about 140 days on nootropics of various kinds, I'm almost instinctually less concerned with inconsequential natter - this has had the negative effect of making me zone out when my neurotic family is saying things to me sometimes
19:20 < strangewarp> It's kind of funny really, but maybe not for them :p
19:21 < strangewarp> It might just be a thing thathappens to people naturally around age 25, though
19:21 <@brownies> heh
19:23 < strangewarp> Oh, actually, I miscounted - it's been about 200 days
19:24 <@brownies> strangewarp: what source did you use/read to figure out dosage and schedules and etc?
19:26 < strangewarp> 30mg noopept per 24 hours is the maximum recommended dose, and half the absolute maximum dose
19:26 < strangewarp> 250mg Cognizin + 250mg Alpha-GPC is what's in Nawgan, a nootropic energy drink that worked well for me in the past
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19:27 < strangewarp> Bit spendy though; might end up dropping the Alpha-GPC once I run out, since the noopept's pills are filled out with 615mg choline citraet anyway
19:27 < strangewarp> citrate*
19:28 < strangewarp> Haven't noticed much difference between Alpha-GPC and choline citrate for absorption, despite the hype
19:29 <@yashgaroth> "absolute maximum dose"? what happens when you OD on noopept?
19:29 < strangewarp> yashgaroth: liver damage
19:30 <@yashgaroth> ah
19:30 < foucist_> strangewarp: i found that after reading some libertarian material & ayn rand for the second time back when i was around 23, i abruptly stopped arguing with anyone about anything of a deep/philosophical nature
19:30 < foucist_> and becamse less concerned with inconsequential natter
19:31 < strangewarp> foucist: weird. I found that after reading some deep/philosophical material for the seccond time when I was around 23, I stopped trying to argue with anyone about anything of a libertarian nature :p
19:31 < foucist_> strangewarp: well i mean i don't argue at all in general
19:31 < foucist_> ever since something flipped in my head
19:32 < foucist_> realized that it's too complex and it depends entirely on people's educations and knowledge.. too hard to educate people when arguing so i don't bother anymore
19:32 < strangewarp> that's the oddest thing, that exact same thing happened to me, right down to the metaphorical sensation of something flipping over in my head
19:34 <@brownies> strangewarp: jesus, the effective dose is a full 50% of the toxic dose?
19:34 <@brownies> that's extremely fucking disconcerting
19:34 < strangewarp> brownies: the effective dose is much less
19:34 < strangewarp> it just gets more effective as you get closer to the toxic dose. I'll never exceed 50% of that, and I'm always keeping careful track of my timing.
19:34 <@brownies> i wouldn't want to mess with anything where the ratio was anything remotely like that
19:35 < strangewarp> shrug, Brainpower packages them at 30mg per capsule, and they're cheaper than the more-diluted gelcap suppliers
19:36 <@brownies> haha. not a very good reason.
19:37 < strangewarp> As long as you don't exceed the absolute limit of 30mg per 12 hours, you're fine. I'm doing 30mg per 24 hours. If I ever get any weird side-effects, I'll drop it cold-turkey, but honestly I doubt that'll happen.
19:39 <@brownies> i like to see 10x, or preferably >100x difference between "effective" and "toxic"
19:39 <@brownies> granted, i'm super-conservative about that sort of thing.
19:40 < ParahSailin_> 50% of the toxic dose?
19:41 < ParahSailin_> what fraction of the ld50 is the effective dose
19:42 < strangewarp> brownies: Man, the effective dose of noopept is (I think something like) 5mg per 24 hours. So that's... 1/12 the toxic dose.
19:43 < strangewarp> ParahSailin_: Unsure what noopept's ld50 is; I just know the dosage at which you risk liver damage.
19:44 < ParahSailin_> so toxic, not lethal-- not so scary then
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19:49 <@brownies> right, it's different from the LD50, but, still, i like my liver.
19:54 < strangewarp> I like my liver as well, which is why I'm being careful :p
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20:29 <@kanzure> beep boop
20:30 <@kanzure> so forrest is telling me about http://hplusmagazine.com/2011/02/06/mutate-or-die-a-w-s-burroughs-biotechnological-bestiary/
20:30 <@kanzure> these guys wanted to make a gene gun to shoot famous people's poop into your testicales
20:31 <@yashgaroth> haha I remember that
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20:32 <@kanzure> hplusmagazine: all the poop that can fit in your nuts
20:32 <@yashgaroth> in your 3d-printed nuts*
20:33 <@yashgaroth> (I was sad but not at all surprised when I found that article eudoxia was referring to)
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20:54 <@kanzure> beep boop
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20:59 <@kanzure> http://googleblog.blogspot.com/2012/09/dive-into-great-barrier-reef-with-first_25.html
21:00 <@brownies> hmm
21:02 < gnusha_> diyhpluswiki.git: 48e29d1 biohacking article from checkbiotech.org
21:04 <@kanzure> that was http://greenbio.checkbiotech.org/news/amateur_scientists_build_lego_style_synthetic_biobricks_public_lab
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