--- Log opened Tue Mar 07 00:00:06 2017
--- Day changed Tue Mar 07 2017
00:00 < nmz787_> .wik codocytes
00:00 < yoleaux> "Codocytes, also known as target cells or Mexican hat cells, are red blood cells that have the appearance of a shooting target with a bullseye. In optical microscopy these cells appear to have a dark center (a central, hemoglobinized area) surrounded by a white ring (an area of relative pallor), followed by dark outer (peripheral) second  ..." -- https://en.wikipedia.org/wiki/Codocytes
00:00 < nmz787_> this says because of lipid or hemoglobin concentration https://theartofmed.wordpress.com/2015/09/05/morphological-abnormalities-of-red-blood-cells/
00:01 < nmz787_> .wik spherocytes
00:01 < yoleaux> "Spherocytosis is an auto-hemolytic anemia (a disease of the blood) characterized by the production of spherocytes (red blood cells (RBCs)) or erythrocytes that are sphere-shaped rather than bi-concave disk shaped." -- https://en.wikipedia.org/wiki/Spherocytes
00:02 < nmz787_> "Hereditary spherocytosis is a genetic disorder, a molecular defect in one or more of the proteins of the red blood cell cytoskeleton, including, spectrin, ankyrin, Band 3, or Protein 4.2. Because the cell skeleton has a defect, the blood cell contracts to its most surface-tension efficient and least flexible configuration, a sphere."
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00:02 < nmz787_> "Allternatively, during immune-mediated hemolytic anemia, there is partial phagocytosis of normal red blood cells by phagocytosis due to the presence of antigens on the surface of the red blood cell. The phagocyte destroys the membrane where the antigen was present, destroying some of the surface area of the cell. Thus, the cell must now shape itself into a sphere, decreasing its surface area:volume
00:02 < nmz787_>  ratio, since the volume of the cell ...
00:02 < nmz787_> ... remains the same. This is known as immune-mediated hemolytic anemia, since the immune system in the form of phagocytes destroys (hemolyses) a portion of the red blood cells, producing spherocytes. Two simple mechanisms."
00:03 < nmz787_> "Though the spherocytes have a smaller surface area through which oxygen and carbon dioxide can be exchanged, they in themselves perform adequately to maintain healthy oxygen supplies. However, they have a high osmotic fragility-when placed into water, they are more likely to burst than normal red blood cells."
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04:35 < kanzure> yes here are some shape things:
04:35 < kanzure> http://diyhpl.us/~bryan/papers2/bio/To%20shape%20a%20cell%20-%20an%20inquiry%20into%20the%20causes%20of%20morphogenesis%20of%20microorganisms%20-%201990.pdf
04:35 < kanzure> http://diyhpl.us/~bryan/papers2/bio/The%20selective%20value%20of%20bacterial%20shape.pdf
04:36 < kanzure> http://diyhpl.us/~bryan/papers2/bio/Bacterial%20morphology%20-%20why%20have%20different%20shapes.pdf
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07:16 < kanzure> delinquentme now has a "fast protein liquid chromatography" machine.
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09:22 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=648a25bc Bryan Bishop: a better link for scriptless scripts >> http://diyhpl.us/diyhpluswiki/transcripts/mit-bitcoin-expo-2017/mimblewimble-and-scriptless-scripts/
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09:40 < kanzure> https://www.reddit.com/r/Nootropics/comments/5xusm6/intranasal_insulin_ini_is_still_an_amazing_noot/
09:40 < kanzure> cluckj: you gonna try it?
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10:24 < mz_o> 44
10:35 < cluckj> sounds like a huge load of crap
10:40 < kanzure> then i have good news! heh
10:40 < cluckj> haha
10:40 < kanzure> because guess what's also ingestible
10:41 < cluckj> is it crap
10:43 < cluckj> idk why you would want to spray insulin up your nose to "bypass the BBB" since insulin kinda just does that on its own
10:44 < kanzure> yes it is crap
10:46 < cluckj> "Lastly, it's being tested as a cure/vaccine for type 1 diabetes."
10:46  * cluckj eyes roll out of his head
10:46 < kanzure> "it's nicer than injecting it"
10:47 < cluckj> lol yikes!
10:47 < cluckj> 160IU a day intranasal with no side effects?!
10:47 < cluckj> that uh....is a lot of insulin
10:48 < cluckj> which makes me think putting it in your nose inactivates the insulin
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11:05 < cluckj> the references look pretty thin, too
11:09 < cluckj> idk the BBB thing makes me think it's bogus thinking, if anything the intranasal route prevents the insulin from being consumed by the body
11:10 < cluckj> in the brain, insulin is just another peptide; brain cells don't regulate their internal glucose with insulin-sensitive receptors
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11:27 < chris_99> nmz787_, did you hear back from that company out of interest re. the analog MEMS mirror thing
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12:05 < nmz787_i1> chris_99: I didn't
12:05 < chris_99> ah
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13:02 < fenn> aww i need cookies to read reddit now? poo
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17:00 < nmz787_i> are there other diybio convos that feature closely-located (physical proximity) people with photenically identical yet grammatically (I mean spelling) different names?
17:01 < kanzure> who you talking about?
17:01 < nmz787_i> phonetically*
17:02 < nmz787_i> 'Sean Donahue' and 'Jo Donoghue'
17:02 < nmz787_i> I guess in this case, it is only their last names
17:05 < nmz787_i> """The maximum capacity of a standard school bus is 72 passengers. However, Student Transportation Services recognizes the safety concerns and problems associated with loading buses to maximum capacity. The general guidelines used are:     Grades K-6: 3 students to a seat    Grades 7-12: 2 students to a seat       Using these guidelines, typical bus maximum capacities will be: Grades K-8: 60 students per standard bus     Grades K-12: 54 students p
17:06 < kanzure> you have textpaste cutoff due to line limits
17:07 < nmz787_i> damn
17:07 < nmz787_i> thought i had multiline plugin added
17:08 < nmz787_i> Grades K-12: 54 students per standard bus     Grades 9-12: 48 students per standard bus"""
17:09 < nmz787_i> anyway, my point is adults probably fit in the 9-12 grade category as far as size goes
17:09 < nmz787_i> so if you are ever organizing large events, or need to do some relative estimation of numbers of people... there's a school bus ref for ya
17:10 < nmz787_i> I don't think I ever remember riding 3 to a seat as a kid tho
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18:06 < jcluck> ?
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18:37 < kanzure> yeah i don't know
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19:05 < nmz787_i> you never think about organizing a biohacker field trip?
19:10 < kanzure> school is something to escape
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19:55 < kanzure> .py3 import hashlib; import requests; print(hashlib.md5().hexdigest(requests.get("https://shells.aachen.ccc.de/~spq/md5.gif").content))
19:55 < yoleaux> TypeError: hexdigest() takes no arguments (1 given)
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22:31 < kanzure> hmph
22:31 < kanzure> a typeerror... fine.
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--- Log closed Wed Mar 08 00:00:52 2017